Copyright ©The Author(s) 2015.
World J Gastroenterol. Mar 21, 2015; 21(11): 3223-3231
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3223
Table 1 Some of these panels depend on a dozen or more variables to derive the scores while others depend only on three or four parameters
Noninvasive testParametersDiseaseAUCRef.
APRIAST, platelet countFibrosis, cirrhosis in mixed patient population0.82Adler et al[40], Hepatology (2008)
Enhanced liver fibrosis (ELF) testHyaluronic acid, tissue inhibitor of matrix metalloproteinase-1, amino terminal propeptide of procollagen type IIINAFLD in children0.92 to 0.99Nobili et al[50], Gastroenterology (2009)
Chronic liver disease0.80Nobili et al[50], Gastroenterology (2009)
HAIRHypertension, ALT, IR indexNAFLD0.90Dixon et al[31], Gastroenterology (2001)
NashTestAlpha2-macroglobulin, haptoglobin, apolipoprotein A1, total bilirubin, GGT, fasting glucose, triglycerides, cholesterol, ALT, AST, age, gender, weight, heightNAFLD0.79Poynard et al[34], BMC Gastroenterology (2006)
A commercial panel from Biopredictive, France
FIB-4Platelets, ALT, AST and ageHCV fibrosis0.76Vallet-Pichard et al[38], Hepatology 2006
NAFLD fibrosis0.80Shah et al[39], Clinical Gastroenterology and Hepatology (2009)
FibroTest/FibroSureα2-macroglobulin , apolipoprotein A1, haptoglobin, total bilirubin, GGTNAFLD fibrosis0.86Ratziu et al[37], BMC gastroenterology (2006)
A commercial panel from Biopredictive, France
Age, AST, plateletHCV fibrosis0.783Hsieh et al[41], Chang Gung Med J (2009)
FibroQCount, PT-INR(F2-4)
Lok indexPlatelet count, PT-INR, AST, ALTHCV fibrosis0.78Lok et al[42], Hepatology (2005)
Forns ScoreAge, platelet count,HCV fibrosis0.86Forns X et al, Hepatology (2002)
GGT, cholesterolFibrosis from all causes0.76Adler et al[40], Hepatology (2008)
BARD ScoreBody-mass index, AST/ALT ratio, type 2 diabetes mellitusNAFLD fibrosis0.67Ruffillo et al[47], Journal of Hepatology (2011)
NAFLD fibrosis scoreAge, hyperglycemia, body mass index, platelet count, albumin, and AST/ALT ratioNAFLD fibrosis0.82Angulo et al[45], Hepatology (2007)
0.68Ruffillo et al[47], Journal of Hepatology (2011)
FibrometerPlatelets, prothrombin index, aspartate aminotransferase, α2-macroglobulin (A2M), hyaluronate, urea, and ageViral and alcoholic chronic liver diseases fibrosis0.883Calès et al[43], Hepatology (2005)
NAFLD0.943Calès et al[44], Journal of Hepatology (2009)