Cyr61/CTGF/Nov family proteins in gastric carcinogenesis

doi:10.3748/wjg.v20.i7.1694

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2014; 20(7): 1694-1700
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1694

Table 1 Nomenclature and characterization of the Cyr61/CTGF/Nov family proteins

CCN proteins (synonyms)	Chromosomal location	Molecular mass, kDa (number of amino acids)
CCN1 (Cyr61; CTGF-2; IGFBP-10/IBP-10; IGFBP-rP4; Cef-10)	1p22.3	42.0 (381)
CCN2 (CTGF; IGFBP-8/IBP-8; IGFBP-rP2; hypertrophic chondrocyte-specific protein 24)	6q23.1	38.1 (349)
CCN3 (Nov; IGFBP-9/IBP-9; IGFBP-rP3)	8q24.1	39.2 (357)
CCN4 (WISP-1; Elm-1)	8q24.22	40.3 (367)
CCN5 (WISP-2; CTGF-3; CTGF-L; Cop-1)	20q13.12	26.8 (250)
CCN6 (WISP-3; LIBC)	6q21	39.3 (354)

CCN: Cyr61/CTGF/Nov; Cyr61: Cysteine-rich angiogenic inducer 61; CTGF: Connective tissue growth factor; IGFBP: Insulin-like growth factor-binding protein; IGFBP-rP: IGFBP-related protein; Cef: Chicken embryo fibroblasts; Nov: Nephroblastoma over-expressed; WISP: Wnt1-inducible signaling pathway protein; Elm: Expressed in low-metastatic cells; Cop-1: Card-only protein 1; LIBC: Lost in inflammatory breast cancer.

Citation: Cheng TY, Wu MS, Hua KT, Kuo ML, Lin MT. Cyr61/CTGF/Nov family proteins in gastric carcinogenesis. World J Gastroenterol 2014; 20(7): 1694-1700
URL: https://www.wjgnet.com/1007-9327/full/v20/i7/1694.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i7.1694