Gastric cancer arising from the remnant stomach after distal gastrectomy: A review

Table 1 Interval between primary gastric cancer and gastric stump carcinoma

Ref.	Previous disease	Interval (mo)	Interval (mo)
	(benign/malignancy)	(all cases)	(benign/malignancy)
Kaneko et al[12], 1998	21/22	180	288/118
Takeno et al[16], 2006	11/21		360/63
Ohashi et al[17], 2007		90
Ahn et al[18], 2008	13/45	150	384/83
Tanigawa et al[19], 2010	578/309	252
Ojima et al[20], 2010	17/21	180	264/108
Komatsu et al[21], 2012	19/14	240	360/144
Li et al[22], 2013	88/24		384/204

Table 2 Interval and location of gastric stump carcinoma by reconstruction

Ref.	Primary reconstruction	Interval (mo)	Location
	Billroth I/II	Billroth I/II	B-I ana/B-I non/B-II ana/B-II non
Takeno et al[16], 2006	21/11	84/276	4/17/6/5
Ohashi et al[17], 2007	71/28		7/64/5/23
Ahn et al[18], 2008	26/25		11/15/16/9
Tanigawa et al[19], 2010	368/519	252/372	81/176/289/114
Komatsu et al[21], 2012	16/16	144/384	2/5/9/2
Li et al[22], 2013	42/70		19/23/45/25

B-I: Billroth I; B-II: Billroth II; ana: Anastomosis site; non: Non-anastomosis site.

Table 3 Helicobacter pylori infection in the patients underwent distal gastrectomy

Ref.	Total infection rate	Billroth I	Billroth II	Roux-en-Y
Onoda et al[31], 2001	65.10%	67.10%	58.30%
Matsukura et al[32], 2003	68.20%	72.20%	58.80%
Abe et al[33], 2005	56.30%	55.60%	58.30%
Chan et al[34], 2007	50.00%	58.60%	66.70%	26.30%

Table 4 Epstein-Barr infection in the patients with gastric stump carcinoma

Ref.	Total infection rate	Billroth I	Billroth II
Tanigawa et al[19], 2000	22.2%	5.9%	32.1%
Nishikawa et al[36], 2002	41.2%	0.0%	58.3%
Kaizaki et al[37], 2005	23.1%	12.5%	30.4%

Table 5 Clinicopathologic characteristics of gastric stump carcinoma

Ref.	Patients age	pT (1/2/3/4)	pN (positive/negative)	pM (positive/negative)	pStage	5-yr survival
Takeno et al[16], 2006	68.7	10/22 (1,2/3,4)	12/20	4/28	21/11 (1,2/3,4)
Ohashi et al[17], 2007	67	67/16/8/17	13/84		77/6/2/23	53.10%
Ahn et al[18], 2008		18/17/0/19	23/29	10/42
Ahn et al[18], 2008	58	15/31 (1/2,3,4)	19/25	17/41	26/32 (1,2/3,4)	63.4% (3-yr)
Tanigawa et al[19], 2010	68	315/245/197/130	534/327	26/861
Komatsu et al[21], 2012	68	10/22 (1/2,3,4)	14/13		17/15 (1/2,3,4)
Li et al[22], 2013		1/3/44/64	66/46	31/81	3/16/62/31	11%

Table 6 Clinicopathological comparison between primary upper third gastric cancer and gastric stump carcinoma

Clinicopathologic chracteristics	Ikeguchi et al[39], 1993	P value	Chen et al[40], 1996	P value	Newman et al[41], 1997	P value	Komatsu et al[42], 2012	P value
pT (1/2/3/4)
PUTGC	63/15/157/31	NS	5/30/88/20	NS	11/15/46/7	NS	69/75/54/9	0.07
GSC	4/3/7/6		0/5/13/7		7/6/11/1		10/10/7/6
pN (negative/positive)
PUTGC	99/167	NS	47/86	NS	24/54	NS	118/89	0.7
GSC	11/9		10/15		14/11		20/13
M (negative/positive)
PUTGC			127/16	NS	Nov-68	NS
GSC			20/5		22/3
5-yr survival
PUTGC	62.1%	NS	25%	0.31	37%	0.1		0.67
GSC	52.5%		46%		63%

PTUGC: Primary upper third gastric cancer; GSC: Gastric stump carcinoma; NS: Not significant.

Table 7 Endoscopic submucosal dissection for gastric stump carcinoma n (%)

Ref.	No. of ESD cases	En bloc resection	Complete resection	Mortality	Delayed bleeding	Perforation
Takenaka et al[44], 2008	31	30 (97)	23 (74)	0	0	4 (13)
Hirasaki et al[45], 2008	17	17 (100)	14 (82)	0	3 (18)	0
Lee et al[46], 2010	13	13 (100)	12 (92.3)	0	0	0
Nonaka et al[47], 2013	139	131 (94)	118 (85)	0	2 (1.4)	2 (1.4)
Tanaka et al[48], 2013	33	33 (100)	31 (94)	0	1 (3)	3 (9)

ESD: Endoscopic submucosal dissection.