MicroRNAs: Promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential

doi:10.3748/wjg.v20.i38.13658

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2014; 20(38): 13658-13666
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13658

Table 1 MicroRNAs as potential diagnostic biomarkers for chemoresistance in gastric cancer

miRNAs	Regulation	Drug resistance cell lines	Target	Ref.
miR-15b	Down ↓	Vincristine	PTEN	[62]
miR-16	Down ↓	Vincristine	PTEN	[62]
miR-19a/b	Up ↑	Doxorubicin, vincristine	PTEN	[77]
miR-21	Up ↑	Cisplatin	PTEN	[78]
miR-106a	Up ↑	Cisplatin	PTEN	[79]
miR-181b	Down ↓	Cisplatin, vincristine	BCL-2	[82]
miR-497	Down ↓	Cisplatin, vincristine	BCL-2	[83]
miR-200b/c	Down ↓	Cisplatin, vincristine	BCL-2, XIAP	[83]
miR-508-5p	Down ↓	Vincristine, doxorubicin	ABCB1, ZNRD1	[81]

The table presents an overview about miRNAs that present different expression pattern between chemotherapy resistant gastric cancer cell lines and controls, including downstream targets and affected chemotherapeutic agents. PTEN: Phosphatase and Tensin homolog; BCL-2: B-cell lymphoma 2; XIAP: X-linked inhibitor of apoptosis protein; ABCB1: ATP-binding cassette sub-family B member 1; ZNRD1: DNA-directed RNA polymerase I subunit RPA12; miRNA: MicroRNA.

Table 2 MicroRNAs as potential therapeutic biomarkers for chemoresistance in gastric cancer

miRNAs	Regulation	Drug resistance	Target in GC	Drug treatment	Ref.
miR-21	Up ↑	Up ↑	PTEN	Cisplatin	[78]
miR-27a	Down ↓	Down ↓	Cyclin-D1, p21	Vincristine, 5-fluouracil, cisplatin, doxorubicin	[87]
miR-106a	Up ↑	Up ↑	PTEN	Cisplatin	[79]
miR-195	Up ↑	Up ↑	CDK6, VEGF	5-azacytidine	[80]
miR-378	Up ↑	Up ↑	CDK6, VEGF	5-azacytidine	[80]
miR-449a	Up ↑	Down ↓	BCL-2, CCDN1	Cisplatin	[88]
miR-508-5p	Up ↑	Down ↓	ABCB1, ZNRD1	Vincristine, doxorubicin	[81]

The table presents an overview about miRNAs that impact on chemotherapy resistance in gastric cancer cell lines, including downstream targets and affected chemotherapeutic agents. PTEN: Phosphatase and Tensin homolog; CDK6: Cylin-dependent kinase 6; VEGF: Vascular endothelial growth factor; BCL-2: B-cell lymphoma 2; CCDN1: Cyclin-D1 gene; ABCB1: ATP-binding cassette sub-family B member 1; ZNRD1: DNA-directed RNA polymerase I subunit RPA12; MiRNA: MicroRNA.

Citation: Matuszcak C, Haier J, Hummel R, Lindner K. MicroRNAs: Promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential. World J Gastroenterol 2014; 20(38): 13658-13666
URL: https://www.wjgnet.com/1007-9327/full/v20/i38/13658.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i38.13658