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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 14, 2014; 20(38): 13658-13666
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13658
Table 1 MicroRNAs as potential diagnostic biomarkers for chemoresistance in gastric cancer
miRNAsRegulationDrug resistance cell linesTargetRef.
miR-15bDown ↓VincristinePTEN[62]
miR-16Down ↓VincristinePTEN[62]
miR-19a/bUp ↑Doxorubicin, vincristinePTEN[77]
miR-21Up ↑CisplatinPTEN[78]
miR-106aUp ↑CisplatinPTEN[79]
miR-181bDown ↓Cisplatin, vincristineBCL-2[82]
miR-497Down ↓Cisplatin, vincristineBCL-2[83]
miR-200b/cDown ↓Cisplatin, vincristineBCL-2, XIAP[83]
miR-508-5pDown ↓Vincristine, doxorubicinABCB1, ZNRD1[81]
Table 2 MicroRNAs as potential therapeutic biomarkers for chemoresistance in gastric cancer
miRNAsRegulationDrug resistanceTarget in GCDrug treatmentRef.
miR-21Up ↑Up ↑PTENCisplatin[78]
miR-27aDown ↓Down ↓Cyclin-D1, p21Vincristine, 5-fluouracil, cisplatin, doxorubicin[87]
miR-106aUp ↑Up ↑PTENCisplatin[79]
miR-195Up ↑Up ↑CDK6, VEGF5-azacytidine[80]
miR-378Up ↑Up ↑CDK6, VEGF5-azacytidine[80]
miR-449aUp ↑Down ↓BCL-2, CCDN1Cisplatin[88]
miR-508-5pUp ↑Down ↓ABCB1, ZNRD1Vincristine, doxorubicin[81]