Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis

doi:10.3748/wjg.v20.i36.13127

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 28, 2014; 20(36): 13127-13132
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13127

Table 1 Selected laboratory values in controls, patients with acute pancreatitis, walled-off pancreatic necrosis and chronic pancreatitis (mean ± SE)

Laboratory values	Control	Acute pancreatitis	Walled-off necrosis	Chronic pancreatitis
Number of control subjects/patients	35	40	33	40
Age (yr)	42 ± 2.2	52 ± 2.6^a	48 ± 2.5^a	45 ± 1.2
Body weight (kg)	79 ± 2.6	78 ± 2.7	72 ± 3.0^a	68 ± 1.5^a
BMI (kg/m²)	25 ± 0.46	25 ± 0.62	24 ± 0.78	22 ± 0.49^a
Serum amylase (U/L)	49 ± 6.1	991 ± 554^a	124 ± 26^a	107 ± 13^a
Serum lipase (U/L)	26 ± 3.0	519 ± 105^a	87 ± 26^a	157 ± 45^a
ALT (U/L)	22 ± 1.5	120 ± 27^a	30 ± 7.5	31 ± 32^a
AST (U/L)	22 ± 6.5	96 ± 22^a	29 ± 6.5	32 ± 1.1^a
Total protein (g/L)	76 ± 0.84	63 ± 1.3^a	70 ± 1.2^a	72 ± 1.1^a
Albumin (g/L)	45 ± 0.75	31 ± 1.3^a	34 ± 1.4^a	44 ± 1.1
Hemoglobin, (g/dL)	15 ± 0.44	13 ± 0.32^a	13 ± 0.30^a	14 ± 0.24^a
BUN (mg/dL)	12 ± 0.45	13 ± 1.2	13 ± 0.72	13 ± 1.1
Bilirubin (mg/dL)	0.87 ± 0.07	2.0 ± 0.39^a	2.0 ± 0.81^a	0.79 ± 0.11
Serum triacylglycerol (mg/dL)	103 ± 5.9	307 ± 80^a	131 ± 6.5^a	115 ± 8.4
Serum cholesterol (mg/dL)	189 ± 3.9	220 ± 24	172 ± 9.7^a	179 ± 7.0^a
Serum glucose (mmol/L)	5.1 ± 0.10	6.8 ± 0.6^a	6.1 ± 0.37^a	6.2 ± 0.25^a
White blood cell count (× 10⁹/L)	6.7 ± 0.25	11 ± 0.73^a	8.2 ± 0.57	8.6 ± 0.49^a
Systolic BP (mmHg)	123 ± 1.0	139 ± 3.6^a	128 ± 22	121 ± 2.4
Diastolic BP (mmHg)	80 ± 1.2	85 ± 2.2^a	78 ± 14	79 ± 1.1
Platelets (× 10⁹/L)	250 ± 8.4	224 ± 18	289 ± 27^a	249 ± 24

^aP < 0.05 vs controls. BMI: Body mass index; ALT: Alanine transaminase; AST: Aspartate transaminase; BUN: Blood urea nitrogen; BP: Blood pressure.

Table 2 The serum concentrations of high-sensitivity C-reactive protein, platelet derived growth factor BB, transforming growth factor β, chemerin and high-mobility group box chromosomal protein 1 in controls, patients with acute pancreatitis, walled-off pancreatic necrosis and chronic pancreatitis (mean ± SE)

Serum concentrations	Control	Acute pancreatitis	Walled-off necrosis	Chronic pancreatitis
hsCRP (mg/L)	1.7 ± 0.19	141 ± 16^a	40± 13^a	23 ± 6.2^a
PDGF-BB (ng/mL)	6.2 ± 0.76	4.0 ± 0.61^a	1.6 ± 0.31^a	12 ± 1.3^a
TGF-β (ng/mL)	39 ± 3.6	39 ± 3.1	34± 4.1	57 ± 3.6^a
Chemerin (ng/mL)	48 ± 2.3	47 ± 2.9	54 ± 3.3	73 ± 7.2^a
HMGB1 (ng/mL)	3.4 ± 0.61	3.4 ± 0.64	3.5 ± 0.58	3.0 ± 0.55

^aP < 0.05 vs controls. hsCRP: High-sensitivity C-reactive protein; PDGF-BB: Platelet derived growth factor BB; TGF-β: Transforming growth factor β; HMBG1: High-mobility group box chromosomal protein 1.

Citation: Stojek M, Adrych K, Rojek L, Smoczynski M, Sledzinski T, Szrok S, Swierczynski J. Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis. World J Gastroenterol 2014; 20(36): 13127-13132
URL: https://www.wjgnet.com/1007-9327/full/v20/i36/13127.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i36.13127