Topic Highlight
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 7, 2014; 20(33): 11574-11585
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11574
Table 1 Main genetic and epigenetic alterations in gastric cancer tissues and their clinical application as biomarkers
AlterationType of alterationClinical applicationRef.
HER-2 amplificationGeneticPrognostic and therapeutic[34-40]
MYC amplificationGeneticProgression and metastasis[52]
TP53 Arg72ProGeneticRisk predictor, prognostic[63-67,69-72]
CDH1 -160 C>AGeneticRisk predictor[76-78]
CDH1 hypermethylationEpigeneticPrognostic, metastasis[167,170,171]
p16 hypermethylationEpigeneticDiagnostic, prognostic and therapeutic[156-160]
Table 2 miRNAs differently expressed in gastric cancer tissues and their clinical application
miRNALevel of expressionClinical applicationRef.
miR-301aUp-regulatedProgression and prognostic[127]
miR-29 familyDown-regulatedPrognostic and therapeutic[128]
miR-146aDown-regulatedMetastasis[129]
miR-10bUp-regulatedProgression and prognostic[130]
miR-107Up-regulatedPrognostic[131]
miR-345 + miR-142Up-regulated (miR-345) and Down-regulated (miR-142)Recurrence and progression[132]
let-7iDown-regulatedPrognostic and therapeutic[133]
miR-221Up-regulatedProgression, prognostic and therapeutic[125,134]
miR-148aDown-regulatedPrognostic[135]
miR-155Down-regulatedProgression and metastasis[136]
miR-129-2-3pDown-regulatedProgression[137]
miR-181bUp-regulatedPrognostic[138]
miR-21Up-regulatedPrognostic[138,139]
Table 3 miRNAs differently expressed in body fluids from gastric cancer patients and their clinical application
miRNABody fluidLevel of expressionClinical applicationRef.
miR-200cBloodUp-regulatedProgression and survival[140]
miR-421Gastric JuiceUp-regulatedScreening[141]
miR-21Gastric JuiceUp-regulatedScreening[142]
miR-106aGastric JuiceUp-regulatedScreening[142]
miR-129-1-3pGastric JuiceDown-regulatedScreening[137]
miR-129-2-3pGastric JuiceDown-regulatedScreening[137]
miR-335BloodUp-regulatedRecurrence and prognostic[143]
miR-221SerumUp-regulatedScreening[144]
miR-744SerumUp-regulatedScreening[144]
miR-376cSerumUp-regulatedScreening[144]
miR-199a-3pPlasmaUp-regulatedProgression, screening[145]