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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 7, 2014; 20(33): 11567-11573
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11567
Table 1 Recent epoch making adjuvant trials showing survival benefit
Reporter/groupRegimenPatients3 ysr/treated3 ysr/control
Macdonald/2001 (SWOG INT0116)FL + (Rad. + FL)Curat. D25041
Cunningham/2006 (MAGIC)EPF (peri-op.)Curat.361231
Sakuramoto/2007 (ACTS-GC)S-1II-III80.170.1
Ychou/2011 (FNCLCC/FFCD)CDDP + 5-FU (peri-op.)Curat.res.381241
Bang/2012 (CLASSIC)Cape. + Oxal.II-IIIB7451
Table 2 Postoperative adjuvant chemotherapy
Reporter/yearRegimens vs Surgery alonePatientsOS 5ysr (%)
TreatedControl
Nakajima/1984MFC + F/MF’C + F’Curat. Res.68.4/62.551.4
Coombes/1990FAMCurat. Res.45.735.4
Krook/1991FACurat. Res.3233
Macdonald/1995FAMI-III3732
Lise/1995FAM2II, III42 mo136 mo1
Grau/1998MMC + FTCurat. Res.67245
Nakajima/1999 (JACOG8801)MF + UFTS(+)85.882.9
Neri/2001ELFN(+)30.2212.6
Bajetta/2002ELFN(+)5248
Nashimoto/2003 (JCOG9206-1)MFC + FCurat. Res. S(-)91.286.1
Chipponi/2004FLPS(+) or N(+)3939
Bouche/2005 (FFCD)FPII-IV46.641.9
De Vita/2007 (GOIM 9602)ELFEIB-IIIB4843.5
Nakajima/2007 (NSAS-GC)UFTT2/N1−286273
Di Costanza/ 2008 (GOIRC)PELFIB-IV47.648.7
Sasako/2011 (ACTS-GC)S-1II-III71.7261.1
Miyashiro/2011CDDPip + CFivS(+), curative6260.9
Noh/2013 (CLASSIC)Cape. + Oxal.II-IIIB78269
Kang/2013 (AMC0201)MMC + 5’FUDR (MF’) vs MF’ + CDDPII-IV61.157.9
Lee/2012 (ARTIST)Cape. + CDDP(XP) vs XP + Rad. + XPCurative, D278.2374.2
Table 3 Phase III Neoadjuvant chemotherapy trials
Reporter/yearRegimenPatientsSurvival benefit
TrialControl
Songun/1999FAMTXCurat. Res.15/27118/29
Stahl/2009PLF + rad. vs PLFCurat. Res. (E-G J)47.4227.7
Schumacher/2010PLCurat. Res.72.7369.9