Retrospective Study
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 28, 2014; 20(32): 11363-11369
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11363
Table 1 Clinical characteristics of 235 consecutive liver transplant patients
VariablesValue
Age (yr)47.11 ± 11.32
MELD score16 (range 6-50)
Child score9 (range 5-15)
GenderMale203 (86.4)
Female32 (13.6)
EtiologyHBV-related140 (59.6)
Hepatocarcinoma55 (23.4)
Others40 (17)
Blood testsBilirubin (μmol/L) (NR < 17.1)162.73 ± 205.39
AST (IU/L) (NR < 50)240.46 ± 556.16
ALT (IU/L) (NR < 40)183.2 ± 325.93
Albumin (g/L) (NR 35-50)34.96 ± 5.47
WBC (× 109/L) (NR 3.5-11)5.96 ± 4.58
Urea (mmol/L) (NR 3-7.1)6.70 ± 5.29
Creatinine (μmol/L) (NR 60-97)94.37 ± 68.98
TC7.91 ± 2.28
ABOA-A85 (36.2)
B-B51 (21.7)
O-O87 (37)
AB-AB12 (5.1)
Table 2 Clinical Fk506-related side effects and cause of death
All events (n)First events only (n)
Rejection3820
Infection5526
Renal insufficiency72
Tumor recurrence3618
Metabolic disorder3421
Cause of death
MODS11
Tumor recurrence22
Graft loss3
Others11
Table 3 Classification of groups according to mean tacrolimus concentration, death rate and related side effects in respective categories
Group1234
TC interval (ng/mL)0-55-77-1010-15
Total number215711938
Number of death89237
Cause of death
MODS4421
Tumor recurrence24133
Graft loss1101
Others1082
Rejection214166
Infection6142411
Renal insufficiency2221
Tumor recurrence57195
Metabolic disorder68155
Table 4 Classification of groups according to standard deviation of Tacrolimus concentration, death rate and related side effects in respective categories
Group123
SD interval0-22-4> 4
Total number2111896
Number of death71822
Cause of death
MODS443
Tumor recurrence2713
Graft loss021
Others155
Rejection12116
Infection52525
Renal insufficiency061
Tumor recurrence31419
Metabolic disorder22012
Table 5 Variables in multivariate Cox regression equation of long-term survival
BSEWalddfSig.Exp(B)LowerUpper
Gender-0.8090.3525.28410.0220.4450.2240.888
Age0.2520.6120.17010.6801.2870.3884.273
Plug score0.6400.3643.09310.0791.8970.9293.870
Meld score-0.2810.2661.11310.2910.7550.4481.272
Diagnosis-0.3510.1624.69110.0300.7040.5120.967
SD of TC0.3450.1535.06310.0241.4121.0451.907
Mean TC-0.9600.3975.83010.0160.3830.1760.835