Yılmaz B, Köklü S, Yüksel O, Arslan S. Serum beta 2-microglobulin as a biomarker in inflammatory bowel disease. World J Gastroenterol 2014; 20(31): 10916-10920 [PMID: 25152594 DOI: 10.3748/wjg.v20.i31.10916]
Corresponding Author of This Article
Bülent Yılmaz, MD, Department of Gastroenterology, Faculty of Medicine, Hacettepe University, Sihhiye, Beytepe Mah., 06100 Ankara, Turkey. bulent.yilmaz@hacettepe.edu.tr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
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World J Gastroenterol. Aug 21, 2014; 20(31): 10916-10920 Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10916
Table 1 Demographic characteristics and comparison of serum Beta 2 microglobulin levels with other laboratory markers between patients and controls n (%)
Controls
UC
CD
P value
n = 30
n = 43
n = 35
Mean age
38.90 ± 11.05
42.72 ± 13.52
38.28 ± 13.15
0.254
Gender (F/M)
18 (60)/12 (40)
17 (40)/26 (60)
19 (54)/16 (46)
0.188
Duration (yr)
5.04 ± 5.81
4.50 ± 3.70
0.729
Inactive/active
14 (33)/29 (67)
12 (34)/23 (66)
Left type 29 (67)
Ileal type 24 (69)
Disease location
Extensive 14 (33)
Ileocolonic 11 (31)
B2-M
1.71 ± 0.44
2.41 ± 0.87
2.24 ± 1.01
0.002
UC vs C 0.002
CD vs C 0.033
UC vs CD 0.642
CRP
0.57 ± 0.83
1.82 ± 2.94
1.59 ± 2.79
0.188
ESR
10.18 ± 11.31
21.21 ± 18.37
22.76 ± 22.81
0.021
UC vs C 0.047
CD vs C 0.026
UC vs CD 0.931
WBC (× 103)
7.09 ± 1.75
7.52 ± 2.84
7.48 ± 3.91
0.190
Albumin
4.43 ± 0.24
4.00 ± 0.62
4.05 ± 0.63
0.005
UC vs C 0.006
CD vs C 0.023
UC vs CD 0.916
Table 2 Overall accuracy and receiver operating characteristic analyses of beta 2 microglobulin and other inflammation markers to differentiate active from inactive ulcerative colitis
AUC
Sensitivity (%)
Specificity (%)
NPV (%)
PPV (%)
B2-M (cut off: 2.02)
0.757
79.3
78.6
88.5
64.7
CRP (cut off: 0.55)
0.731
67.9
75.0
86.4
50.0
WBC (× 103)
0.656
72.4
58.3
80.8
46.7
(cut off: 6.50)
ESR (cut off: 14.5)
0.677
69.0
58.3
80.0
43.8
Table 3 Comparison of serum beta 2 microglobulin levels with other laboratory markers between active and inactive ulcerative colitis patients
Inactive CD
Active CD
P value
n = 14
n = 29
B2-M
1.88 ± 0.41
2.66 ± 0.92
0.004
CRP
0.41 ± 0.27
2.43 ± 3.34
0.046
ESR
14.00 ± 7.85
24.20 ± 20.65
0.106
WBC (× 103)
6.41 ± 1.47
7.96 ± 3.16
0.119
Albumin
3.99 ± 0.50
4.01 ± 0.67
0.948
Table 4 Comparison of serum beta 2 microglobulin levels with other laboratory markers between active and inactive Crohn’s disease patients
Inactive CDn = 12
active CDn = 23
P value
B2-M
1.73 ± 0.31
2.50 ± 1.15
0.033
CRP
0.24 ± 0.12
2.23 ± 3.22
0.050
ESR
11.45 ± 11.21
28.17 ± 25.08
0.044
WBC (× 103)
7.81 ± 2.28
7.33 ± 4.53
0.742
Albumin
4.50 ± 0.42
3.83 ± 0.60
0.002
Table 5 Overall accuracy and receiver operating characteristic analyses of beta 2 microglobulin and other inflammation markers between active and inactive ulcerative colitis patients
AUC
Sensitivity (%)
Specificity (%)
NPV (%)
PPV (%)
B2-M (Cut off: 1.84)
0.828
78.3
75.0
85.7
64.3
CRP (Cut off: 0.35)
0.903
78.3
81.8
90.0
64.3
WBC (× 103)
0.379
47.8
56.5
68.8
33.3
(Cut off: 6.80)
ESR (Cut off: 13.5)
0.761
78.3
72.7
85.7
61.5
Citation: Yılmaz B, Köklü S, Yüksel O, Arslan S. Serum beta 2-microglobulin as a biomarker in inflammatory bowel disease. World J Gastroenterol 2014; 20(31): 10916-10920