Perinodular ductular reaction/epithelial cell adhesion molecule loss in small hepatic nodules

Table 1 Postoperative follow-up of patients with hepatocellular carcinoma ≤ 3 cm, hepatocellular carcinoma with nodule > 3 cm and high-grade dysplastic nodules

Group	Follow-up time (mo)	Tumor-free survival time (mo)	Tumor-free survival rate		Early recurrence	Recurrence rate	Metastasis rate	Mortality rate
			1-yr	3-yr
HCC > 3 cm	21.7	9.0	4/26	0/26	18/26	20/26	3/26	20/26
HCC ≤ 3 cm	60.1	35.5	18/20	7/20	7/20	14/20	3/20	1/20
HGDN	41.9	35.4	20/20	10/20	3/20	3/20	0/20	0/20

HCC: Hepatocellular carcinomas; HGDN: High-grade dysplastic nodules.

Table 2 Ductular reaction distribution among different groups

Group	DR/EpCAM			DR/CK7			DR/CK19
	-	+/-	+	-	+/-	+	-	+/-	+
HCC1	17	8	1	13	11	2	16	9	1
HCC2	11	6	3	7	5	8	9	7	4
HGDN	1	7	12	2	5	13	1	5	14
CLRN	0	5	21	0	4	22	0	5	21
CIR	0	3	17	0	2	18	0	4	16

HCC1: HCC > 3 cm; HCC2: HCC ≤ 3 cm. HCC: Hepatocellular carcinoma; HGDN: High-grade dysplastic nodules; CLRN: Cirrhotic large regenerative nodule; CIR: Cirrhosis; DR: Ductular reaction; CK: Cytokeratin.