Retrospective Study
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 14, 2014; 20(30): 10545-10552
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10545
Table 1 Indications for liver transplantation in those developing early and late hepatic artery thrombosis
Indication for LTHAT% HAT for indicationEarly HATLate HAT
Malignancy103.1% (10/327)64
Hepatitis B cirrhosis62.3% (6/265)51
Acute liver failure35% (3/60)21
Hepatic echinococcosis114.3% (1/7)10
Table 2 Univariate analysis for recipient and donor factors associated with early hepatic artery thrombosis n (%)
VariablePatientsEarly HATP value
Number of LTs74414 (1.9)-
Recipient gender
Male627 (84.3)13 (2.1)
Female117 (15.7)1 (0.9)0.370
Recipient age (yr)
> 6063 (8.5)2 (3.2)
≤ 60681 (91.5)12 (1.8)0.460
Aetiology
Malignancy327 (44)6 (1.8)
Benign417 (56)8 (1.9)0.930
Child-Pugh class
A233 (31.3)3 (1.3)
B291 (39.1)5 (1.7)
C220 (29.6)6 (2.7)0.510
MELD score14 (6-59)12.5 (6-36)0.538
Pre-LT abdominal operation
Yes222 (29.8)2 (0.9)
No522 (70.2)12 (2.3)0.199
TACE history
Yes67 (9.0)2 (3.0)
No677 (91.0)12 (1.2)0.490
Diabetes
Yes40 (5.4)1 (2.5)
No744 (94.6)13 (1.8)0.770
Blood group
Match649 (87.2)12 (1.8)
Compatible89 (12.0)1 (1.1)
Incompatible6 (0.8)1 (16.7)0.025
Recipient/donor wt. ratio
≥ 1.15112 (15.1)6 (5.4)
< 1.15632 (84.9)8 (1.3)0.003
Donor gender
Female113 (15.0)3 (2.7)
Male641 (85.0)11 (1.7)0.495
Donor age (yr)
≥ 604 (0.5)0
< 60750 (99.5)14 (1.9)0.780
Table 3 Univariate analysis for potential intraoperative factors associated with early hepatic artery thrombosis n (%)
VariablePatientsEarly HATP value
Type of allograft
Whole size54410
LDLT1964
Split400.948
Dual grafts
Yes10 (1.3)1 (10.0)
No734 (98.7)13 (1.8)0.057
Complex arterial reconstruction
Yes30 (4.0)3 (10.0)
No714 (96.0)11 (1.5)0.001
HA anastomosis time (min)
> 80153 (20.6)8 (5.2)
≤ 80591 (79.4)6 (1.0)0.001
Biliary reconstruction
R-D74 (9.9)1 (1.4)
D-D670 (90.1)13 (1.9)0.723
Operation time (h)
> 10208 (28.0)9 (4.3)
≤ 10536 (72.0)5 (0.9)0.002
Blood (U)
≥ 7383 (51.5)12 (3.1)
< 7361 (48.5)2 (0.6)0.010
FFP (U)
≥ 6295 (39.7)10 (3.4)
< 6449 (60.3)4 (0.9)0.014
Platelets
Yes223 (29.9)2 (0.9)
No521 (70.1)12 (2.3)0.199
WIT (min)51 (36-105)54 (38-82)> 0.1
CIT (min)359 (109-782)341 (134-542)> 0.1
Table 4 Univariate analysis for potential postoperative factors associated with early hepatic artery thrombosis n (%)
VariablePatientsEarly HATP value
Episode of rejection
Yes42 (5.6)1 (2.4)
No702 (94.4)13 (1.9)0.806
Retransplantation
Yes18 (2.4)0
No726 (97.6)14 (1.9)0.708
Infection
Yes126 (16.9)3 (2.4)
No618 (83.1)11 (1.8)0.651
Blood
Yes244 (32.8)9 (3.7)
No500 (67.2)5 (1.0)0.011
FFP
Yes240 (32.3)8 (3.3)
No504 (67.7)6 (1.2)0.044
Platelets
Yes60 (8.1)1 (1.7)
No684 (91.9)13 (1.9)0.898
Hyperglycemia/diabetes
Yes268 (36.0)5 (1.9)
No476 (64.0)9 (1.9)0.981
PVT
Yes9 (1.2)0 (11.1)
No735 (98.8)14 (1.9)0.679
Bile leak
Yes17 (2.3)0
No727 (97.7)14 (1.9)0.721
Table 5 Independent predictors of early hepatic artery thrombosis after liver transplantation
VariablePvalueOR95%CI
Recipient/donor wt. ratio ≥ 1.150.0084.4991.487-13.608
HA anastomosis time > 80 min0.0045.4291.725-17.086
Intraoperative blood transfusion ≥ 7 U0.0174.0591.290-12.770
Postoperative blood transfusion0.0156.8981.463-32.526
Table 6 Univariate analysis for risk factors associated with early hepatic artery thrombosis n (%)
VariablePatientsLate HATP value
Diabetes pre-LT
Yes40 (5.4)2 (5.0)
No704 (94.6)4 (0.6)0.037
Type of LT
Whole size544 (73.1)4 (0.7)
LDLT196 (26.3)1 (0.5)
Split4 (0.5)1 (25)< 0.001
Operation time
> 10 h208 (28.0)4 (1.7)
≤ 10 h536 (72.0)2 (0.4)0.034
Retransplantation
Yes181
No72650.023
Hyperglycemia/post-LT diabetes
Yes268 (36.0)5 (1.9)
No476 (64.0)1 (0.2)0.025
Episode of rejection
Yes48 (6.5)2 (4.2)
No696 (93.5)4 (0.6)0.050
Table 7 Independent predictors of late hepatic artery thrombosis after liver transplantation
VariableP valueOR95%CI
Operation time > 10 h0.0506.3940.998-40.977
Episode of rejection0.00416.9362.424-118.317
Retransplantation0.00121.7933.302-143.836