Impairment of secondary peristalsis in Barrett’s esophagus by transnasal endoscopy-based testing

Table 1 Clinical characteristics of the subjects in each group n (%)

	Control (n = 25)	SSBE (n = 16)	LSBE (n = 8)
Sex (male/female)	19/6	15/1b	8/0b
Age (yr)	32 ± 7	38.4 ± 14.4	38.0 ± 14.0
BMI (kg/m2)	22 ± 2.8	22.7 ± 3.1	22.2 ± 3.5
No. smokers	7 (28)	4 (25)	4 (50)bd
No. drinkers	20 (80)	14 (87.6)	7 (87.5)
No. Helicobacter pylori antibody positive	4 (18.2)	2 (12.5)	0 (0)bd
No. with erosive reflux esophagitis	1 (4)	7 (43.8)b	5 (62.5)bd

Data are expressed as absolute numbers (percentage) or mean ± SD.

^bP < 0.01 vs control;

^dP < 0.01 vs patients with short segment Barrett’s esophagus (SSBE). LSBE: Long segment Barrett’s esophagus; BMI: Body mass index.

Table 2 Results of the acid perfusion test in each group

	Lag time (s)	Intensity rate	APSS
Control group	6.1 ± 2.3	162 ± 150	9.0 ± 8.7
Barrett’s esophagus	5.8 ± 2.2	162 ± 164	7.7 ± 6.1
SSBE	5.7 ± 2.3	199 ± 189	8.8 ± 6.9
LSBE	6.1 ± 2.0	88 ± 54	5.4 ± 3.3

Data are the mean ± SD. There were no significant differences between the groups in any of the parameters measured. Lag time is the time from the start of infusion until the onset of acid-induced symptoms, intensity rate refers to the intensity of the symptoms (scored over the range 1-10), and the acid perfusion sensitivity score (APSS) was calculated as the product of intensity rate and lag time. SSBE: Short segment Barrett’s esophagus; LSBE: Long segment Barrett’s esophagus.

Table 3 Frequency of primary and secondary contractions in the different groups following infusion of either physiological saline or acid

	No. primary contractions		No. secondary contractions
	Physiological saline	Acid	Physiological saline	Acid
Control group	1.3 ± 3.3	0.3 ± 0.9	8.0 ± 2.8	8.4 ± 2.4
Barrett’s esophagus	0.8 ± 1.2	0.7 ± 1.5	6.3 ± 3.1	7.2 ± 2.8
SSBE	1.1 ± 1.4	0.6 ± 1.0	7.3 ± 3.2	8.1 ± 2.9
LSBE	0.4 ± 0.7	1.0 ± 2.1	4.1 ± 1.2bd	5.3 ± 1.2bd

Data are the mean ± SD. Within the same infusion groups:

^bP < 0.01 vs control;

^dP < 0.01 vs patients with short segment Barrett’s esophagus (SSBE). LSBE: Long segment Barrett’s esophagus.