Clinical Trials Study
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 14, 2014; 20(26): 8653-8659
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8653
Table 1 Concentration of plasma free amino acids in controls and esophageal squamous cell carcinoma patients
Amino acid (μmol/L)ControlESCCP value
Aspartate0.04 ± 0.030.06 ± 0.07< 0.001
Glutamate0.37 ± 0.300.07 ± 0.06< 0.001
Asparagine0.06 ± 0.040.05 ± 0.040.36
Serine0.27 ± 0.510.12 ± 0.120.51
Glycine0.14 ± 0.090.07 ± 0.03< 0.001
Histidine0.28 ± 0.170.16 ± 0.11< 0.001
Arginine0.09 ± 0.050.09 ± 0.150.77
Threonine0.21 ± 0.210.08 ± 0.08< 0.001
Taurine0.26 ± 0.180.13 ± 0.12< 0.001
Alanine0.98 ± 1.060.19 ± 0.18< 0.001
Proline0.08 ± 0.060.06 ± 0.070.19
Cystine0.01 ± 0.020.03 ± 0.040.01
Tyrosine0.07 ± 0.060.06 ± 0.030.50
Valine0.24 ± 0.160.23 ± 0.290.80
Methionine0.12 ± 0.190.02 ± 0.01< 0.001
Lysine0.09 ± 0.050.08 ± 0.070.45
Isoleucine0.29 ± 0.330.12 ± 0.08< 0.001
Leucine0.21 ± 0.160.12 ± 0.08< 0.001
Phenylalanine0.12 ± 0.070.07 ± 0.03< 0.001
Table 2 Association of plasma free amino acid profiles with clinicopathological characteristics
Pathological differentiation
Lymph node metastasis
Clinical stage
Amino acidMid/poorWellP valuePositiveNegativeP valueIb2> Ib2P value
Aspartate0.06 ± 0.070.09 ± 0.040.040.00 ± 0.000.01 ± 0.010.010.01 ± 0.010.00 ± 0.000.14
Glutamate0.03 ± 0.020.07 ± 0.05< 0.0010.03 ± 0.020.09 ± 0.06< 0.0010.11 ± 0.040.06 ± 0.06< 0.001
Asparagine0.07 ± 0.040.18 ± 0.16< 0.0010.03 ± 0.020.06 ± 0.040.010.09 ± 0.060.04 ± 0.02< 0.001
Serine0.11 ± 0.080.22 ± 0.11< 0.0010.05 ± 0.030.16 ± 0.14< 0.0010.23 ± 0.190.08 ± 0.040.01
Glycine0.06 ± 0.040.09 ± 0.02< 0.0010.10 ± 0.080.19 ± 0.10< 0.0010.22 ± 0.120.14 ± 0.090.01
Histidine0.06 ± 0.030.12 ± 0.220.220.04 ± 0.030.08 ± 0.03< 0.0010.09 ± 0.030.06 ± 0.03< 0.001
Arginine0.05 ± 0.050.12 ± 0.09< 0.0010.06 ± 0.040.10 ± 0.190.350.14 ± 0.280.07 ± 0.040.34
Threonine0.10 ± 0.100.17 ± 0.130.020.05 ± 0.060.10 ± 0.090.060.06 ± 0.070.06 ± 0.07< 0.001
Taurine0.12 ± 0.120.28 ± 0.20< 0.0010.06 ± 0.060.17 ± 0.13< 0.0010.20 ± 0.130.11 ± 0.100.01
Alanine0.04 ± 0.030.09 ± 0.090.020.07 ± 0.070.26 ± 0.18< 0.0010.30 ± 0.220.15 ± 0.140.02
Proline0.02 ± 0.040.03 ± 0.050.5520.04 ± 0.020.07 ± 0.080.020.09 ± 0.100.05 ± 0.050.18
Cystine0.04 ± 0.020.09 ± 0.03< 0.0010.02 ± 0.050.03 ± 0.050.740.03 ± 0.040.02 ± 0.050.59
Tyrosine0.12 ± 0.060.36 ± 0.38< 0.0010.04 ± 0.020.08 ± 0.03< 0.0010.10 ± 0.030.05 ± 0.02< 0.001
Valine0.02 ± 0.010.03 ± 0.01< 0.0010.09 ± 0.060.30 ± 0.330.010.45 ± 0.470.14 ± 0.070.02
Methionine0.07 ± 0.100.09 ± 0.030.360.02 ± 0.010.03 ± 0.01< 0.0010.04 ± 0.010.02 ± 0.01< 0.001
Lysine0.07 ± 0.030.19 ± 0.06< 0.0010.05 ± 0.040.09 ± 0.080.030.09 ± 0.030.07 ± 0.080.33
Isoleucine0.06 ± 0.040.18 ± 0.07< 0.0010.05 ± 0.030.16 ± 0.07< 0.0010.21 ± 0.070.09 ± 0.05< 0.001
Leucine0.05 ± 0.020.09 ± 0.02< 0.0010.05 ± 0.040.15 ± 0.08< 0.0010.20 ± 0.080.08 ± 0.05< 0.001
Phenylalanine0.00 ± 0.000.01 ± 0.010.120.04 ± 0.020.08 ± 0.03< 0.0010.10 ± 0.020.05 ± 0.02< 0.001