Interactions between pork consumption, CagA status and IL-1B-31 genotypes in gastric cancer

doi:10.3748/wjg.v20.i25.8151

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Jul 7, 2014 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Gastroenterol. Jul 7, 2014; 20(25): 8151-8157
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8151

Table 1 Demographic data of cases and controls n (%)

Characteristic		Cases	Controls	t/χ²	P value
Characteristic		n = 171	n = 367
Age (yr, mean ± SD)		56.93 ± 14.01	56.81 ± 13.90	0.093¹	0.440
Gender
	Male	118 (69.01)	243 (66.21)	0.412	0.521
	Female	53 (30.99)	124 (33.79)	0.412	0.521
Education
	Primary	51 (29.82)	117 (31.88)	0.332	0.847
	Secondary	84 (49.12)	179 (48.77)
	Tertiary and postgraduate	36 (21.06)	71 (19.35)
BMI (kg/m²)
	≤ 25	110 (64.33)	244 (66.49)	0.365	0.794
	> 25	61 (35.67)	123 (33.51)	0.365	0.794
H. pylori CagA positive		101 (59.06)	163 (44.41)	10.018	0.002^a
IL-1B-31
	TT	41 (23.98)	89 (24.25)	0.005	0.997
	TC	84 (49.12)	180 (49.05)
	CC	46 (26.90)	98 (26.70)
	C carrier	130 (76.02)	278 (75.75)
Pork consumption
	< 25 g/d	89 (52.05)	177 (48.23)	0.680	0.410
	≥ 25 g/d	82 (47.95)	190 (51.77)	0.680	0.410

¹For t test.

^aP < 0.05 vs control group. BMI: Body mass index; H. pylori: Helicobacter pylori; IL: Interleukin.

Table 2 Joint effects of pork consumption, CagA status and interleukin-1B-31 genotypes on the risk of gastric cancer¹

Genotype of IL-1B-31	Pork consumption
	Low (< 25 g/d)				High (≥ 25 g/d)
	Hp CagA (-)		Hp CagA (+)		Hp CagA (-)		Hp CagA (+)
	Case/control	OR	Case/control	OR	Case/control	OR	Case/control	OR
TT	9/15	1.00	16/15	1.00	11/30	1.00	5/29	1.00
TC	11/58	0.42 (0.14-1.11)	30/39	0.71 (0.31-1.98)	20/49	1.25 (0.47-2.81)	23/34	2.98 (0.99-11.30)
CC	12/27	0.71 (0.27-2.36)	11/23	0.46 (0.16-1.54)	27/25	0.86 (0.29-2.35)	16/23	3.11 (1.08-12.66)
C carrier	23/85	0.45 (0.18-1.37)	41/62	0.69 (0.33-1.63)	27/74	1.00 (0.48-2.06)	39/57	3.07 (1.17-10.79)

¹Adjusted for the following confounding factors: age, gender, education, smoking, alcohol, and family history. P for multiplicative interaction: Pork consumption and Helicobacter pylori (H. pylori) CagA status: 0.11 [adjusted by age, gender, education, smoking, alcohol, family history and interleukin (IL)-1B-31 C carrier]; Pork consumption and IL-1B-31 C carrier: 0.048 (adjusted by age, gender, education, smoking, alcohol, family history and H. pylori CagA status).

Citation: Wang XQ, Terry PD, Cheng L, Yan H, Wang JS, Wu WA, Hu SK. Interactions between pork consumption, CagA status and IL-1B-31 genotypes in gastric cancer. World J Gastroenterol 2014; 20(25): 8151-8157
URL: https://www.wjgnet.com/1007-9327/full/v20/i25/8151.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i25.8151