Wang XQ, Terry PD, Cheng L, Yan H, Wang JS, Wu WA, Hu SK. Interactions between pork consumption, CagA status and IL-1B-31 genotypes in gastric cancer. World J Gastroenterol 2014; 20(25): 8151-8157 [PMID: 25009387 DOI: 10.3748/wjg.v20.i25.8151]
Corresponding Author of This Article
Xiao-Qin Wang, Associate Professor, Department of Statistics and Epidemiology, School of Medicine, Xi’an Jiaotong University, 76 West Yanta Road, Xi’an 710061, Shaanxi Province, China. wangxiaoqin@mail.xjtu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 7, 2014; 20(25): 8151-8157 Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8151
Interactions between pork consumption, CagA status and IL-1B-31 genotypes in gastric cancer
Xiao-Qin Wang, Paul D Terry, Li Cheng, Hong Yan, Jian-Sheng Wang, Wen-An Wu, Sen-Ke Hu
Xiao-Qin Wang, Hong Yan, Department of Statistics and Epidemiology, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Paul D Terry, Departments of Public Health and Surgery, University of Tennessee, Knoxville, TN 37996, United States
Li Cheng, Department of Nursing, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Jian-Sheng Wang, Department of Thoracic Oncosurgery, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Wen-An Wu, Department of Radiation Oncology Cancer Hospital of Shaanxi Province, Xi’an 710061, Shaanxi Province, China
Sen-Ke Hu, Lab Center of Public Health Department, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: Wang XQ and Hu SK performed the majority of experiments; Wang JS and Cheng L provided vital reagents and analytical tools and were also involved in editing the manuscript; Terry PD revised the manuscript for important intellectual content and also were involved in designing the study; Wu WA and Wang JS collected all the human materials; Yan H and Wang XQ provided financial support for this work; Wang XQ designed the study and wrote the manuscript.
Supported by Grant of Health Department of Shaanxi Province, No. 2009K12-02
Correspondence to: Xiao-Qin Wang, Associate Professor, Department of Statistics and Epidemiology, School of Medicine, Xi’an Jiaotong University, 76 West Yanta Road, Xi’an 710061, Shaanxi Province, China. wangxiaoqin@mail.xjtu.edu.cn
Telephone: +86-29-82657015 Fax: +86-29-82657015
Received: December 25, 2013 Revised: February 9, 2014 Accepted: April 2, 2014 Published online: July 7, 2014
Core Tip
Core tip: It is widely known that infectious, dietary, and genetic factors are implicated in gastric carcinogenesis, which is a long, complicated, and multi-stage process. The Helicobacter pylori (H. pylori) virulence factor CagA has been shown to be polymorphic and to contribute to disease pathogenesis in an allele-dependent manner. The interleukin (IL)-1 gene plays an important role in determining the long-term outcome of H. pylori infection. Dietary factors such as pork consumption may contribute to the malignancy process in synergy with these genetic factors and infectious agents. Our study further explores potential interactions among dietary (pork intake), infectious (H. pylori CagA positive) and genetic factors (IL-1B-31 genotypes) on gastric cancer risk.
