Prospective Study
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 14, 2014; 20(22): 7011-7018
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.7011
Table 1 Clinical and biochemical characteristics of cirrhotic patients
VariableTotal (n = 100)NGT (n = 30)SAGT (n = 70)
Age, yr53.9 ± 11.849.0 ± 12.056.0 ± 11.11
BMI, kg/m226.9 ± 4.226.4 ± 4.4027.21 ± 4.15
Males60 (60)18 (60)42 (60)
Etiology: Alcohol47 (47)14 (46.6)33 (47.1)
HBV4 (4)1 (3.3)3 (4.2)
HCV13 (13)2 (6.6)11 (15.7)
Autoimmunity10 (10)3 (10)7 (10)
Cryptogenic26 (26)10 (33.3)16 (22.8)
Liver biopsy44 (44)13 (43.3)31 (44.2)
Length of LC, mo21.6 + 27.621.4 ± 30.621.7 ± 33.2
Hemoglobin, g/dL11.8 ± 2.311.6 ± 2.111.9 ± 2.3
Platelets, × mm3128140 ± 89501159186 ± 112108114834 ± 73269
INR1.3 ± 0.31.2 ± 0.31.36 ± 0.32
Creatinine, mg/dL0.8 ± 0.20.90 ± 0.330.83 ± 0.2
Albumin, g/dL3.2 ± 0.733.33 ± 0.713.21 ± 0.74
ALT, UI/L46.5 ± 40.848.9 ± 53.945.4 ± 34.0
Total bilirubin, mg/dL1.71 ± 0.901.55 ± 0.881.78 ± 0.91
Fasting plasma insulin, μU/mL15.9 ± 10.211.9 ± 7.618.2 ± 113
HOMA2 score2.67 ± 1.62.36 ± 1.464.6 ± 3.34
Child-Pugh A47 (47)15 (50)32 (45.7)
B53 (53)15 (50)38 (54.2)
Child Pugh score6.8 ± 1.86.5 ± 1.616.82 ± 1.67
MELD score8.94 ± 4.88.3 ± 5.29.21 ± 4.63
Survival, d123714481116
(990-1925)(1256-1925)(990-1790)5
Table 2 Annual cumulated survival of cirrhotic patients n (%)
Year(s)NGT (n = 30)SAGT (n = 70)P value (χ2test)
12 (93)9 (87)0.36
24 (83.2)14 (79)0.34
34 (83.2)23 (51.4)0.04
44 (83.2)24 (47.5)0.03
55 (71.6)26 (31.7)0.02
Table 3 Causes of death n (%)
CauseTotal (n = 31)
Variceal bleeding8 (25.8)
Liver failure6 (19.3)
SBP e infection5 (16.2)
Hepatorenal syndrome5 (16.2)
HCC4 (12.9)
Renal impairment2 (6.4)
Cardiovascular1 (3.2)
Table 4 Univariate and multivariate analyses: Independent predictors of death
VariableHR95%CIP valueHR95%CIP value
Creatinine1.61.2-40.20.0302.620.5-3.460.650
Albumin3.41.8-22.30.0156.30.4-32.10.180
INR2.21.6-32.40.0503.50.3-23.60.230
Child-Pugh B7.23.4-33.00.00038.22.0-28.50.020
Child Pugh score5.22.9-25.80.00810.22.4-21.90.008
MELD score8.14.2-18.70.00112.36.4-33.60.001
SAGT4.52.0-15.20.0423.22.8-54.20.010
Fasting serum insulin1.21.0-33.50.0403.20.1-27.30.320