Epigenetics: An emerging player in gastric cancer

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Jun 7, 2014 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2014; 20(21): 6433-6447
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6433

Table 1 Examples of epigenetic alterations found in gastric cancer

Alteration source	Expression	Alteration target	Ref.
DNA hypermethylation	Down	Signal pathway mediator genes (ADAMTS9, BCL2L10, BCL6B, BNIP3, CXCL12, DAPK, DKK1, DKK3, DLL1, FBLN1, GATA4, HOXD10, LMX1A, OPCML, PCDH10, RELN, SFRP proteins, , SOX17, TIMP3, VEZT)	[100-120]
	Down	Chromatin-modifying enzyme genes (MGMT, SMARCA5)	[93,140]
	Down	MicroRNA genes (Let-7f, MIR10B, MIR34C, MIR137, MIR155, MIR182, MIR195, MIR200B, MIR200C, MIR210, MIR212, MIR338, MIR375, MIR378, MIR429, MIR449)	[127-139]
DNA hypomethylation	Up	ALDH2, ASCL2, MTHFR, SULF1, SULF2, TERF2	[122-126]
	Up	MicroRNA gene (MIR93)	[83]
H3/H4 hyperacetylation	Up	MYC	[107]
H3/H4 deacetylation	Down	GATA, RND3	[149,150]
H3 dephosphorylation	Down	c-JUN, HSP70	[151]
MicroRNA function	Down	Chromatin-modifying enzyme genes (DNMT1, DNMT3A, DNMT3B, UHRF1)	[141,142]

Citation: Kang C, Song JJ, Lee J, Kim MY. Epigenetics: An emerging player in gastric cancer. World J Gastroenterol 2014; 20(21): 6433-6447
URL: https://www.wjgnet.com/1007-9327/full/v20/i21/6433.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i21.6433