Zhang H, Zhu YQ, Wu YQ, Zhang P, Qi J. Detection of promoter hypermethylation of Wnt antagonist genes in fecal samples for diagnosis of early colorectal cancer. World J Gastroenterol 2014; 20(20): 6329-6335
Corresponding Author of This Article
Jian Qi, PhD, MD, Department of Gastroenterology and Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, Hubei Province, China. firstname.lastname@example.org
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1Represents the P value vs normal subjects. Sensitivity represents the ability of the DNA methylation test to detect the presence of at least one hypermethylated gene. CRC: Colorectal cancer; SFRP: Secreted frizzled related protein; WIF-1: Wnt inhibitory factor-1.
Table 2SFRP2 and WIF-1 gene primer sequences for methylation-specific polymerase chain reaction assays
Product size (bp)
Annealing temperature (°C)
SFRP: Secreted frizzled related protein; WIF-1: Wnt inhibitory factor-1.
Table 3 Hypermethylation status of SFRP2 and WIF-1 in fecal DNA samples n (%)
Citation: Zhang H, Zhu YQ, Wu YQ, Zhang P, Qi J. Detection of promoter hypermethylation of Wnt antagonist genes in fecal samples for diagnosis of early colorectal cancer. World J Gastroenterol 2014; 20(20): 6329-6335