Research Report
Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 21, 2014; 20(15): 4393-4400
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4393
Table 1 Clinical characteristics n (%)
VariableLDLT (n = 40)DDLT ( n= 80)P value
Age (yr)48.6 ± 9.749.5 ± 8.90.614
Gender> 0.999
Male34 (85.0)68 (85.0)
Female6 (15.0)12 (15.0)
MELD score0.354
6-97 (17.5)22 (27.5)
10-1928 (70.0)49 (61.2)
20-293 (7.5)8 (10.0)
30-402 (5.0)1 (1.3)
Child-Pugh score0.898
A12 (30.0)25 (31.2)
B18 (45.0)38 (47.5)
C10 (25.0)17 (21.3)
Previous hepatic resection3 (7.5)6 (7.5)> 0.999
Preoperative down-staging treatment12 (30.0)29 (36.3)0.496
Liver cirrhosis> 0.999
Hepatitis B cirrhosis39 (97.5)77 (96.3)
Alcoholic cirrhosis01 (1.3)
Autoimmune cirrhosis01 (1.3)
No cirrhosis1 (2.5)1 (1.3)
Comorbidities
Hypertension4 (10.0)8 (10.0)> 0.999
Diabetes mellitus4 (10.0)8 (10.0)> 0.999
Cardiac disease01 (1.3)> 0.999
Cerebrovascular disease1 (2.5)4 (5.0)0.872
Previous abdominal surgery11 (27.5)13 (16.3)0.146
Table 2 Preoperative serological detection outcomes n (%)
VariableLDLT (n = 40)DDLT (n = 80)P value
Serum alpha-fetoprotein0.331
< 400 ng/mL25 (62.5)57 (71.2)
≥ 400 ng/mL15 (37.5)23 (28.8)
Blood group0.132
A10 (25.0)25 (31.3)
B11 (27.5)28 (35.0)
AB2 (5.0)9 (11.3)
O17 (42.5)18 (22.5)
HBVsAg positive40 (100.0)76 (95.0)0.369
HBV DNA0.297
< 1000 copies/mL20 (50.0)32 (40.0)
≥ 1000 copies/mL20 (50.0)48 (60.0)
HCV antibody positive00> 0.999
Table 3 Perioperative outcomes and oncological characteristics n (%)
VariableLDLT ( n= 40)DDLT (n = 80)P value
Duration of operation (min)553 ± 105445 ± 75< 0.001
Estimated blood loss (mL)1188 ± 8241035 ± 10720.055
Intraoperative transfusion24 (60.0)35 (43.8)0.093
Tumor pathological type0.557
HCC39 (97.5)79 (98.8)
ICC01 (1.3)
cHCC-CC1 (2.5)0
Tumor size (cm)3.8 ± 1.94.1 ± 2.30.708
Tumor number0.238
Single27 (67.5)62 (77.5)
Multiple13 (32.5)18 (22.5)
Vascular invasion3 (7.5)4 (5.0)0.890
Within Milan criteria24 (60.0)48 (60.0)> 0.999
Outside Milan criteria (Pittsburgh staging)> 0.999
I12 (30.0)24 (30.0)
IVa2 (5.0)4 (5.0)
IVb2 (5.0)4 (5.0)
Table 4 Perioperative complications (modified Clavien-Dindo classification) n (%)
GradeLDLT ( n= 40)DDLT (n = 80)P value
Grade I3 (7.5)5 (6.3)> 0.999
Wound infection34
Mental symptom01
Grade II18 (45.0)52 (65.0)0.036
Postoperative bacterial infection1135
Virus infection22
Bile leak20
Hypertension12
Mental symptom14
Acute rejection05
Peripheral nerve injury01
Intra-abdominal bleeding12
Subdural hematoma01
Grade IIIa3 (7.5)00.063
Biliary stricture10
Hepatic artery thrombosis10
Wound dehiscence10
Grade IIIb2 (5.0)10 (12.5)0.333
Intra-abdominal bleeding05
Bile leak21
Wound dehiscence02
Biliary stricture01
Hepatic artery thrombosis01
Grade IVa02 (2.5)0.552
Renal insufficiency02
Grade IVb1 (2.5)1 (1.3)> 0.999
MODS11
Grade V1 (2.5)4 (5.0)0.872
Death14
Overall21 (52.5)46 (57.5)0.603
Table 5 Overall biliary complications n (%)
Biliary complicationsLDLT (n = 40)DDLT (n = 80)P value
Perioperative period5 (12.5)2 (2.5)0.073
Bile leak41
Biliary stricture11
Long-term follow-up period6 (15.0)4 (5.0)0.129
Biliary stricture64
Overall11 (27.5)6 (7.5)0.003
Table 6 Survival outcomes n (%)
VariableLDLT (n = 40)DDLT (n = 80)P value
Survival status
Alive without relapse27 (67.5)51 (63.8)
Alive with disease3 (7.5)3 (3.8)
Died of relapse5 (12.5)16 (20.0)
Died of other causes5 (12.5)10 (12.5)
Overall survival0.372
1-yr89.8%84.9%
5-yr74.1%66.6%
Relapse-free survival0.749
1-yr81.2%80.3%
5-yr72.9%70.9%