Colonic and anal metastases from pancreato-biliary malignancies

Table 1 Summarising characteristics of the 2 cases

Demographic information	Mode of presentation	Initial investigations and findings	Site of primary lesion	Site of metastases	Histology of metastasis	Outcome
79, female	Presented with obstructive jaundice	EUS, CT, ERCP, tissue diagnosis obtained after Whipple resection	Ampullary	Anal canal	Adeno carcinoma, PB type. CK7/CK17/MUC1 positive, (negative for K20/CDX2/MUC2)	Palliation
63, female	Presented with obstructive jaundice	Colonoscopy and biopsy, staging CT	Hilum of bile ducts	Sigmoid colon	Microscopy Immunohistochemistry strong CK7 staining, with occasional positive staining for CK20; (negative CDX2, CK17 and ER immunoreactivity)	Palliative percutaneous biliary stenting and chemotherapy

CT: Computed tomography; EUS: Endoscopic ultrasound scan; ERCP: Endoscopic retrograde cholangiopancreatography.