Brief Article
Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 21, 2014; 20(11): 3025-3032
Published online Mar 21, 2014. doi: 10.3748/wjg.v20.i11.3025
Table 1 Patient characteristics, n (%)
VariableWith bone metastasis (n = 66)Without bone metastasis (n = 72)
Age, yr
Range23-8422-78
Mean5859
Sex
Male46 (70)53 (71)
Female20 (30)19 (29)
Liver resection
With55 (83)58 (81)
Without11 (17)14 (19)
Set
Training set38 (58)38 (53)
Validation set28 (42)34 (47)
TNM stage of HCC
I00
II08
III064
IV660
Method for
metastasis detection1/
MRI/CT54
ECT/SPET-CT66
PET-CT12
Table 2 Significant differential peptide peaks between bone metastasis hepatocellular carcinoma group and bone metastasis-free hepatocellular carcinoma group
Serial numberm/zPTTA (t)P-W testPAD_1PAD_2HCC groups (n = 38)Bone metastasis HCC groups (n = 38)
11780.73.60 × 10-41.58 × 10-40.0260.048110.3333.7
21866.58.48 × 10-52.80 × 10-40.1360.500750.11703.5
32131.66.30 × 10-22.99 × 10-40.0310.00142.3129.8
42880.42.00 × 10-33.68 × 10-40.1000.005142.5294.9
51532.47.30 × 10-26.32 × 10-40.0010.00170.8138.1
62901.99.57 × 10-49.38 × 10-40.0780.06599.3182.2
72489.87.70 × 10-22.00 × 10-30.2080.00131.170.5
83061.11.02 × 10-12.00 × 10-30.0100.00130.174.9
92234.39.00 × 10-33.00 × 10-30.1180.00391.1171.5
102864.17.00 × 10-33.00 × 10-30.0290.009135.5337.0
Table 3 Sequences of significant differential peptides
m/zam/zbDelta massPeptide sequenceProtein nameAccession number
1780.71779.89520.8048GEYYLQNAFLVAYTKAlpha-fetoproteinIPI00022443
1866.51866.8657-0.3657TATSEYQTFFNPRTFGProthrombinIPI00019568
2131.62131.9237-0.3237NLPSDSQDLGQHGLEEDFMSerglycinIPI00019372
2880.42880.4904-0.0904RPGVLSSRQLGLPGPPDVPDHAAYHPFIsoform 2 of inter-alpha-trypsin inhibitor heavy chain H4IPI00218192
1532.41532.8213-0.4213CSRDNTLKVIDLRIsoform 1 of autophagy-related protein 16-2IPI00300536
2489.82489.28100.5190YTIAALLSPYSYSTTAVVTNPKETransthyretinIPI00022432
2234.32235.1993-0.8993KREEAPSLRPAPPPISGGGYRFibrinogen beta chainIPI00298497