Copyright
©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 14, 2014; 20(10): 2634-2640
Published online Mar 14, 2014. doi: 10.3748/wjg.v20.i10.2634
Published online Mar 14, 2014. doi: 10.3748/wjg.v20.i10.2634
Table 1 Frequency of hyperplastic polyps subtypes n (%)
Table 2 Description of molecular alterations reported in serrated lesions
| Ref. | Population | Molecularalterations | Serrated polyp | Carcinoma | |||||
| HP | SSA | TSA | MP | Serrated ADC | |||||
| MVHP | GCHP | MPHP | |||||||
| Kim et al[24] | South Korea | KRAS | 16.7% | 72.7% | 25.0% | 12.5% | NA | NA | NA |
| BRAF | 66.7% | 0.0% | 25.0% | 60.7% | NA | NA | NA | ||
| MSI-H | NA | NA | NA | 1.8% | NA | NA | NA | ||
| CIMP positive | 73.3% | 18.2% | 75.0% | 76.8% | NA | NA | NA | ||
| Sandmeier et al[30] | Switzerland | KRAS | 17.0% | 25.0% | NA | NA | NA | ||
| BRAF | 83.0% | 63.0% | NA | NA | NA | ||||
| MSI-H | 0.0% | 0.0% | NA | NA | NA | ||||
| CIMP positive | NA | NA | NA | NA | NA | ||||
| Kim et al[10] | United States | KRAS | 6.0% | 8.0% | NA | 8.0% | 17.0% | 25.0% | NA |
| BRAF | 88.0% | 75.0% | NA | 81.0% | 76.0% | 75.0% | NA | ||
| MSI-H | 0.0% | 0.0% | NA | 0.0% | 3.0% | 0.0% | NA | ||
| CIMP positive | 41.%% | 8.0% | NA | 44.0% | 43.0% | 50.0% | NA | ||
| O´Brien et al[40] | United States | KRAS | 13.2% | 42.9% | NA | 6.9% | NA | NA | 0.0% |
| BRAF | 76.3% | 21.4% | NA | 82.9% | NA | NA | 82.0% | ||
| MSI-H | 0.0% | 0.0% | NA | 0.0% | NA | NA | 81.8% | ||
| CIMP positive | 47.4% | 14.3% | NA | 75.9% | NA | NA | 90.0% | ||
| Spring et al[27] | Australia | KRAS | 11.0% | 50.0% | NA | 8.0% | 0.0% | 43.0% | NA |
| BRAF | 70.0% | 20.0% | NA | 78.0% | 66.0% | 57.0% | NA | ||
| MSI-H | NA | NA | NA | NA | NA | NA | NA | ||
| CIMP positive | NA | NA | NA | NA | NA | NA | NA | ||
| Konishi et al[34] | Japan | KRAS | 13.0% | 8.0% | NA | 22.7% | NA | ||
| BRAF | NA | 32.0% | NA | 40.9% | NA | ||||
| MSI-H | 8.0% | 36.0% | NA | 5.0% | NA | ||||
| CIMP positive | NA | NA | NA | NA | NA | ||||
| Yang et al[33] | United States | KRAS | 13.2% | 46.2% | NA | 7.1% | 28.0% | NA | NA |
| BRAF | 76.3% | 23.1% | NA | 82.1% | 60.0% | NA | NA | ||
| MSI-H | NA | NA | NA | NA | NA | NA | NA | ||
| CIMP positive | 47.4% | 15.4% | NA | 75.0% | 80.0% | NA | NA | ||
- Citation: Yamane L, Scapulatempo-Neto C, Reis RM, Guimarães DP. Serrated pathway in colorectal carcinogenesis. World J Gastroenterol 2014; 20(10): 2634-2640
- URL: https://www.wjgnet.com/1007-9327/full/v20/i10/2634.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i10.2634