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World J Gastroenterol. Mar 14, 2014; 20(10): 2634-2640
Published online Mar 14, 2014. doi: 10.3748/wjg.v20.i10.2634
Serrated pathway in colorectal carcinogenesis
Letícia Yamane, Cristovam Scapulatempo-Neto, Rui Manuel Reis, Denise Peixoto Guimarães
Letícia Yamane, Rui Manuel Reis, Denise Peixoto Guimarães, Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, 14780-000 São Paulo, Brazil
Cristovam Scapulatempo-Neto, Department of Pathology, Barretos Cancer Hospital, Barretos, 14780-000 São Paulo, Brazil
Rui Manuel Reis, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4704-553 Braga, Portugal
Denise Peixoto Guimarães, Department of Endoscopy, Barretos Cancer Hospital, Barretos, 14780-000 São Paulo, Brazil
Author contributions: Yamane L contributed to study conception and design, literature search and manuscript writing; Scapulatempo-Neto C contributed to manuscript writing, revising it critically for important intellectual content; Reis RM contributed to study conception and design and manuscript writing, revising it critically for important intellectual content; Guimarães DP contributed to conception and design, manuscript writing and final approval of the version to be published.
Correspondence to: Denise Peixoto Guimarães, MD, PhD, Department of Endoscopy, Barretos Cancer Hospital, Rua Antenor Duarte Vilella, 1331, Barretos, 14780-000 São Paulo, Brazil. guimaraes.dp@gmail.com
Telephone: +55-173-3216600 Fax: +55-173-3216600
Received: May 3, 2013
Revised: June 15, 2013
Accepted: July 4, 2013
Published online: March 14, 2014
Core Tip

Core tip: This paper reviews the pathologic and molecular features of serrated polyps and the serrated pathway to colorectal cancer and its clinical impact. The serrated pathway has recently emerged as the second pathway leading to colorectal cancer, and the genetic alterations occurring in this pathway are not still clarified. It’s imperative to understand the molecular profile of colorectal lesions with higher malignancy potential to implement a surveillance and screening approach in order to prevent colorectal cancer development.