Liu GF, Tang D, Li P, Wang S, Xu YX, Long AH, Zhou NL, Zhang LL, Chen J, Xiang XX. S-1-based combination therapy vs S-1 monotherapy in advanced gastric cancer: A meta-analysis. World J Gastroenterol 2014; 20(1): 310-318 [PMID: 24415887 DOI: 10.3748/wjg.v20.i1.310]
Corresponding Author of This Article
Xiao-Xing Xiang, Adjunct Professor, Chief Physician, Department of Gastroenterology and Hepatology, Subei People’s Hospital of Jiangsu Province (Clinical Medical College of Yangzhou University), Nantong West Road No.98, Yangzhou 225000, Jiangsu Province, China. yzxiangxx@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 5 Outcome of toxicity meta-analysis comparing S-1-based combination therapy vs S-1 monotherapy as first-line treatment in advanced gastric cancer
Toxicity
S-1-based therapy
S-1 monotherapy
OR (95%CI)
Pvalue
Heterogeneity
Grade 3-4
n/N
n/N
Pvalue
I2
Leucopenia
44/392
12/398
4.06 (2.11-7.81)
< 0.01
0.728
0.00%
Neutropenia
127/392
43/398
3.94 (2.70-5.77)
< 0.01
0.334
11.90%
Anaemia
77/392
30/398
5.96 (3.03-11.73)
< 0.01
0.423
0.00%
Thrombocytopenia
11/392
10/398
0.33 (0.10-1.12)
0.076
0.900
0.00%
Anorexia
91/392
47/398
2.40 (0.79-7.28)
0.122
0.000
83.40%
Nausea
41/392
16/398
2.80 (0.92-8.55)
0.070
0.048
62.00%
Fatigue
26/392
20/398
1.35 (0.74-2.46)
0.336
0.506
0.00%
Vomiting
15/392
9/398
1.71 (0.74-3.96)
0.207
0.707
0.00%
Diarrhea
35/392
16/398
2.41 (1.31-4.44)
< 0.01
0.614
0.00%
Stomatitis
7/392
2/398
2.52 (0.71-8.79)
0.151
0.994
0.00%
Citation: Liu GF, Tang D, Li P, Wang S, Xu YX, Long AH, Zhou NL, Zhang LL, Chen J, Xiang XX. S-1-based combination therapy vs S-1 monotherapy in advanced gastric cancer: A meta-analysis. World J Gastroenterol 2014; 20(1): 310-318