Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2013; 19(43): 7735-7742
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7735
Table 1 Number of individuals with SLC25A13 mutations and carrier prevalence in the Thai population according to geographical distribution
RegionMutation [I] (c.851_854delGTAT)Mutation XIX (g.IVS16ins3kb)p.Met1?Total carriers (p.Met1? not included)Total carriers (p.Met1? included)
Bangkok (n = 142)2 (1/71)12 (1/71)5 (1/28)14 (1/36)8 (1/18)1
Central (n = 387)03 (1/129)17 (1/23)3 (1/129)20 (1/19)
Northeastern (n = 498)4 (1/125)027 (1/18)4 (1/125)31 (1/16)
Northern (n = 291)1 (1/291)3 (1/97)21 (1/14)4 (1/74)25 (1/12)
Southern (n = 219)1 (1/219)1 (1/219)15 (1/15)2 (1/110)17 (1/13)
Total (n = 1537)8 (1/192)9 (1/171)85 (1/18)17 (1/90)101 (1/15)
P value20.180.0670.366NA0.413
Table 2 Frequency of SLC25A13 mutations in population studies
MutationNumber of carriers (allele frequency)
Japanese[21]Japanese[13,14]Korean[13]Chinese[13]Thai (present study)
I851del44 (0.48)4 (0.15)11 (0.22)45 (0.54)8 (0.26)
IIIVS11 + 1G > A3 (0.36)9 (0.33)8 (0.16)0 (0.00)0 (0.00)
III1638ins230 (0.00)1 (0.04)1 (0.02)3 (0.04)0 (0.00)
IVS225X0 (0.00)5 (0.18)0 (0.00)0 (0.00)0 (0.00)
VIVS13 + 1G > A2 (0.24)1 (0.04)0 (0.00)0 (0.00)0 (0.00)
VIIR605X0 (0.00)0 (0.00)2 (0.04)0 (0.00)NA
VIIIE601X1 (0.12)0 (0.00)0 (0.00)0 (0.00)0 (0.00)
XIVS6 + 5G > A0 (0.00)0 (0.00)0 (0.00)15 (0.18)NA
XIR184X0 (0.00)0 (0.00)0 (0.00)1 (0.01)NA
XIXIVS16ins3kb0 (0.00)1 (0.04)NANA9 (0.29)
p.Met1?NANANANA85 (2.77)
n4201372245541691537
p.Met1? not included
Number of carriers1020226417
Carrier rate1/421/651/1121/651/90
Homozygote rate1/71001/170001/500001/170001/33000
p.Met1? included
Number of carriersNA101
Carrier rate1/15
Homozygote rate1/900