Cengiz M, Candır BA, Yılmaz G, Akyol G, Ozenirler S. Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage? World J Gastroenterol 2013; 19(42): 7412-7418 [PMID: 24259972 DOI: 10.3748/wjg.v19.i42.7412]
Corresponding Author of This Article
Mustafa Cengiz, MD, Department of Gastroenterology, Gazi University Faculty of Medicine, 06500 Ankara, Turkey. drmustafacen@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 14, 2013; 19(42): 7412-7418 Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7412
Table 1 Demographic and laboratory features of non-alcoholic steatohepatitis, simple steatosis and healthy control groups
Factor
NASH group (n = 62)
Steatosis group (n = 32)
Healthy control group (n = 30)
P-value
Age mean ± SD
48.81 ± 12.21
47.25 ± 12.58
48.03 ± 9.54
NS
Gender (male)
30 (48.3)
18 (56.2)
18 (60)
NS
BMI (kg/m2)
27.13 ± 0.37
25.97 ± 0.67
24.22 ± 0.45
< 0.01
Hemoglobin (g/dL)
14.10 ± 0.16
14.51 ± 0.28
13.91 ± 0.11
NS
Platelet (× 103/mL)
245.5 ± 34.73
244.5 ± 13.8
260 ± 4.47
NS
WBC (k/UL)
6950 ± 319
7250 ± 330
7350 ± 146
NS
Neutrophil ratio
59.39% ± 1.20%
59.87% ± 1.20%
59% ± 1.1%
NS
Lymphocyte ratio
31.29% ± 1.09%
29.88% ± 1.10%
32% ± 0.78%
NS
RDW
14.28% ± 0.25%
13.37% ± 0.12%
12.96% ± 0.14%
< 0.01
MPV (fL)
8.63 ± 1.30
8.49 ± 1.06
8.20 ± 0.59
NS
MCV (fL)
86.34 ± 0.88
87.98 ± 1.37
85.5 ± 0.82
NS
ALT (IU/L)
54 ± 8.1
45 ± 3.97
32.5 ± 1.49
< 0.01
AST (IU/L)
40.05 ± 6.04
40.05 ± 3.01
24 ± 1.39
< 0.01
ALP (IU/L)
87.5 ± 9.09
81.5 ± 3.91
61 ± 1.87
< 0.01
GGT (IU/L)
61 ± 13.4
32 ± 3.4
27 ± 2.5
< 0.01
Albumin (g/dL)
4.36 ± 0.73
4.5 ± 0.42
4.9 ± 0.75
< 0.01
Creatinine
0.78 ± 0.033
0.79 ± 0.023
0.72 ± 0.014
NS
BUN (mg /dL)
12.25 ± 0.85
14.2 ± 0.67
13.46 ± 0.71
NS
Diabetes mellitus
19 (30.6)
9 (28.1)
0 (0)
NS
Hypertension
22 (35.4)
7 (21.8)
0 (0)
NS
Table 2 Red cell distribution width correlated with clinical characteristics and histological features of non-alcoholic steatohepatitis
Factor
r-value
P-value
Age (yr)
0.245
< 0.01
BMI (kg/m2)
0.131
NS
Gender
-0.251
< 0.01
Fibrosis
0.579
< 0.01
Inflammation
0.207
NS
Steatosis
0.121
NS
Ballooning
0.175
NS
NASH
0.217
NS
Table 3 Univariate analyses for predicting liver fibrosis
OR
95%CI
P-value
Age
1.05
1.004-1.109
< 0.05
Gender
1.46
0.516-4.171
NS
Platelet
0.98
0.988-0.996
< 0.01
ALT
1.08
0.976-1.004
NS
AST
0.98
0.963-1.007
NS
ALP
1.015
1.002-1.028
< 0.05
GGT
1.002
0.998-1.007
NS
RDW
1.73
1.242-2.409
< 0.01
Albumin
0.418
0.158-1.105
NS
BMI
1.012
0.847-1.209
NS
Table 4 Multivariate analyses for advanced liver fibrosis
OR
95%CI
P-value
ALP
1.005
0.993-1.018
NS
RDW
1.75
1.129-2.711
< 0.05
Age
1.02
0.957-1.086
NS
Platelet
0.991
0.981-1.001
NS
Albumin
1.016
0.291-3.545
NS
Citation: Cengiz M, Candır BA, Yılmaz G, Akyol G, Ozenirler S. Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage? World J Gastroenterol 2013; 19(42): 7412-7418