Pharmacological challenges in chronic pancreatitis

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Nov 14, 2013 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2013; 19(42): 7302-7307
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7302

Table 1 Pathophysiological and lifestyle related effects on drug absorption

Pathophysiology	Effect on drug absorption
Low intraluminal pH	The drugs ability to cross the luminal wall
Motility disorder	Delayed drug effect
Bacterial overgrowth	Decreased absorption due to diarrhea or structural abnormalities
Pancreatic secretion	Lack of enzymes leads to inactivation of pro-drugs
Steatorrhea	Problems with absorption of lipophilic drugs
Low body mass index	Increased plasma concentration

Citation: Olesen AE, Brokjaer A, Fisher IW, Larsen IM. Pharmacological challenges in chronic pancreatitis. World J Gastroenterol 2013; 19(42): 7302-7307
URL: https://www.wjgnet.com/1007-9327/full/v19/i42/7302.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i42.7302