Risk of ileal pouch neoplasms in patients with familial adenomatous polyposis

Table 1 Summary of 25 reports of ileal pouch adenomas in familial adenomatous polyposis

Ref.	Study	Year	Operation	n	Type of pouch	Findings	% of adenoma	Time to neoplasia
Beart et al[17]	Case	1982	Kock	1	Kock pouch	Tubulovillous Adenomas		6 yr
Wolfstein et al[18]	Case	1982	IAA	2	Soave	Adenomas in 2 pts		3 and 7 yr
Shepherd et al[19]	Retro	1987	IPAA	12	N	Tubular Adenoma in 2 pts	16.7
Stryker et al[20]	Case	1987	Brooke ileostomy	1	Kock pouch	Tubular Adenomas		12 yr
Nugent et al[16]	Retro	1993	IPAA	38	N	Tubular Adenoma in 5 pts	13.2	4 yr (1-7)
Bertoni[21]	Pros	1995	IAA	3	N	Tubular Adenoma in 2 pts	66.7	53.7-75.4 mo
Wu et al[22]	Pros	1998	IPAA	26	S/J-pouch 9/16, 1 N	Tubular Adenoma in 11 pts	42.3	1-14 yr
Valle et al[23]	Case	2001	IPAA	5	N	Adenomas	20	5 yr
Thompson-Fawcett et al[24]	Pros	2001	Kock 5, IPAA 28	33	N	Adenoma in 14 pts (with microadenoma 20 pts)	42.4 (60.6)	7 yr (1-19)
Parc et al[4]	Pros	2001	IPAA	85	J-pouch	30 pts (28 grossly visible, 2 microadenoma)	35.3	Cumulative risk of 7%, 35%, and 75% at 5, 10, and 15 yr
Polese et al[25]	Retro	2002	IPAA	46	S/W/J-pouch 2/1/43, Kock 4	Adenoma in 2 of 30 pts	6.7	risk of Adenoma after 8 yr; 20%, (9-11 yr)
Beveridge et al[26]	Case	2004	IPAA	2	J-pouch 1, Kock 1	2 large VA, VA		4-10 yr
Vrouenraets et al[27]	Case	2004	IPAA	1	J-pouch	Adenomas with focal severe dysplastic change		6 yr
Groves et al[28]	Pros	2005	Kock 4, IPAA 56	60	W/J-pouch 13/43, Kock 4	Mild dysplasia 23, more advanced 11	56.7	6 yr (1-17)
Nilubol et al[29]	Pros	2007	IPAA	10	N	Tubular Adenoma in 1of 9 pts	11.1	11.3 yr
Moussata et al[30]	Retro	2008	IPAA	23	N	Low-grade 16, high-grade 1	73.9	4.76 yr (1-14)
Friederich et al[31]	Pros	2008	IPAA	212	N	Adenoma 74 pts, AAP 25 pts	46.7	Cumulative risk of 16% and 42.2% at 5 and 10 yr
Schulz et al[32]	Pros	2008	IPAA	35	N	Low-grade 8	22.8	mean of 5 yr
Tajika et al[33]	Retro	2009	Kock 8, IPAA 16	24	J-pouch	16 pts, (advanced 1, carcinoma 2)	66.7	Cumulative risk of 13%, 43%, and 72% at 5, 10, and 20 yr
Kang et al[34]	Case	2010	Kock	2	Kock pouch	2 (the largest one is 15mm in size)
Banasiewicz et al[35]	Pros	2011	IPAA	165	J-pouch	Low-grade 13, high-grade 8, neoplasia 5	15.8	Cumulative risk of 50%, Low-grade at 15 yr, high-grade at 17.5 yr, neoplasia 18.5 yr
Tonelli et al[36]	Pros	2012	IPAA	69	S/J-pouch 25/29, SIMM 15	Adenoma 25 pts, carcinoma 2 pts	39.1	Cumulative risk of 28.5% at 5 yr
Makni et al[37]	Case	2012	IPAA	1	J-pouch	Adenoma and carcinoma		10 yr
Wasmuth et al[38]	Retro	2013	IPAA	61	N	14 pts	23	Estimated cumulative rate of first Adenoma diagnosed was 38%
Pommaret[39]	Retro	2013	IPAA	118	J-pouch	57 pts (12 advanced Adenomas)	48.3	15 yr

Study: Type of study; Retro: Retrospective series; Pros: Prospective series; n: Number of patients in the study; IPAA: Ileal pouch-anal anastomosis; Kock: Kock continent ileostomy; N: Not described; AV: Anal verge; pts: Patients.

Table 2 Summary of 21 cases of ileal pouch cancer in familial adenomatous polyposis

Ref.	Year	Sex	Operation	Type of pouch	Staging of initial surgery	Age of pouch (yr)	Shape	Size (mm)	Staging of pouch cancer	No. of pouch polyps	Time to cancer (yr)	Outcome	Interval since last endoscopy (yr)
Bassuini et al[40]	1996	M	IPAA	/handsewn	No cancer	28	Large polypoid	N	T3,N+	N	3	N	No follow-up
Palkar et al[41]	1997	F	IPAA	J-pouch handsewn	No cancer	39	Large polypoid	40 × 35	T4N0	Exist	4.7	Alive	0.3
Kim et al[42]	1997	N	N	N	N	N	N	N	N	N	N	N	N
Cherki et al[43]	2003	F	IPAA	J-pouch handsewn	TisN0M0	35	N	N	T3N1M1	N	3.5	Died	0.5
Linehan et al[44]	2007	M	IPAA	/double stapled	Dukes A	30	N	N	T3N0	N	9	Alive	No follow-up
Friederich et al[31]	2008	M	IPAA	/handsewn	No cancer	21.3	N	N	Dukes C	0	14	N	4.4
		M	IPAA	/stapled	No cancer	26.7	N	N	Dukes B	0	10	N	2.1
		M	IPAA	/handsewn	No cancer	16	N	N	Dukes B	N	16	N	No follow-up
		F	IPAA	/stapled	No cancer	29.6	N	N	Dukes B	exist	6	N	0.6
Tajika et al[45]	2009	F	IPAA	J-pouch/handsewn	TisN0M0	46	Type 2	30 × 25	T4N2M0	0	8.6	Died 3Y	0.75
		M	Kock	Kock/handsewn	No cancer	48	Type 1	40 × 35	T3N0M0	10 <	20	Died by U	No follow-up
Ault et al[46]	2009	M	IPAA	S-pouch/handsewn	Four cancer	61	ND	20-30	T2N1	N	11	Died by U	6
		F	IPAA	ND	No cancer	40	Type 1	N	N	N	13	meta	No follow-up
Lee et al[47]	2009	F	IPAA	J-pouch/	T2N0	56	Type 2	30 × 25	T3N2	0	7	meta 2Y	4
Banasiewicz et al[35]	2011	N	IPAA	J-pouch/	N	N	N	N	N	N	N	N	N
		N	IPAA	J-pouch/	N	N	N	N	N	N	N	N	N
		N	IPAA	J-pouch/	N	N	N	N	N	N	N	N	N
		N	IPAA	J-pouch/	N	N	N	N	N	N	N	N	N
Tonelli et al[36]	2012	M	IPAA	S-pouch/handsewn	No cancer	26	Type 2	20 <	T3N0M0	ND	3	Died 6 mo	1
		F	IPAA	S-pouch/handsewn	TisN0M0	47	IIa + IIc	N	T2N0M0	0	11	Alive at 56 mo	0.5
Makni et al[37]	2012	F	IPAA	J-pouch/	No cancer	26	N	20	N	Many	10	Died 1Y+	0.66

M: Male; F: Female; IPAA: Ileal pouch-anal anastomosis; Kock: Kock continent ileostomy; N: Not described; AV: Anal verge; U: Unrelated disease; Time to cancer: Interval between cancer diagnosis and pouch construction.