Hepatitis C and pregnancy

Table 1 Prevalence of serum anti-hepatitis C virus and hepatitis C virus RNA in in studies examining ≥ 3000 pregnant mothers

Ref.	No. screened	Anti-HCV+	HCV RNA+
Hillemanns et al[3]	3712	0.94%	57%
Conte et al[4]	15250	2.40%	72%
Ward et al[5]	4729	0.80%	72%
Baldo et al[6]	4008	1.70%	42.50%
Goldberg et al[7]	3548	0.60%	NA
Kumar et al[8]	8130	1.03%	NA
Sami et al[9]	5902	1.80%	NA
Ohto et al[10]	22664	0.50%	54%
Seisdedos et al[11]	474539	0.15%	NA
Ugbebor et al[12]	5760	3.60%	NA
Pinto et al[13]	115386	0.10%	NA
Urbanus et al[14]	4563	0.30%	NA
Mean		1.16%	59.75%

HCV: Hepatitis C virus; NA: Not available.

Table 2 Proportion of intravenous drug use or blood transfusion risk factors in pregnant hepatitis C virus-positive mothers

Ref.	No. screened	IVDU	BT
Paccagnini et al[16]	70	79.00%	9.00%
Zanetti et al[17]	94	17.00%	13.00%
Granovski et al[18]	147	79.00%	NA
Hillemanns et al[19]	35	20.00%	11.00%
Resti et al[20]	403	25.00%	4.50%
Gervais et al[21]	26	35.00%	19.00%
Conte et al[4]	370	32.00%	18.00%
Baldo et al[6]	40	45.00%	2.50%
Mast et al[22]	242	52.30%	19.80%
Mean		42.60%	12.10%

IVDU: Intravenous drug use; BT: Blood transfusion.

Table 3 Effect of hepatitis C virus on the course of pregnancy

	Hillemanns et al[19]	Jabeen et al[49]	Floreani et al[50]
Miscarriages	NA	12.4% vs 22.2%	-
Typical obstetric complications	-	-	-
Preterm delivery	29% vs 19%	4.5% vs 3.2%	NA
Rate of cesarean section	42% vs 21% (P = 0.004)	5.6% vs 12.7%	41.50%
Fetal outcome	Good	Good	Good

NA: Not available.