Up-to-seven criteria for hepatocellular carcinoma liver transplantation: A single center analysis

Table 1 Baseline, tumor characteristics, and overall and tumor-free survival rates of the liver transplantation recipients

	Milan criteria	In up-to-seven criteria	Out up-to-seven criteria	P value	P value	P value
	(Group 1), n = 58	(Group 2), n = 90	(Group 3) n = 120	1 vs 2	2 vs 3	1 vs 3
Baseline characteristics
Gender (M/F)	51/7	81/9	109/11	0.859	0.648	0.552
Age (yr)	48.4 ± 10.9	46.8 ± 10.8	45.4 ± 10.0	0.390	0.315	0.067
BMI (kg/m2)	23.3 ± 2.4	23.5 ± 2.3	23.3 ± 2.0	0.715	0.739	0.963
Underlying LD				0.775	0.452	0.312
HBV	54	83	78
HCV	0	1	1
No hepatic virus	4	6	16
HBV-DNA(-/+)	29/39	45/45	82/38	0.838	0.070	0.174
DDLT/LDLT	36/22	62/28	98/23	0.393	0.022	0.003
Child score (A/B/C)	29/16/13	49/23/18	66/37/17	0.492	0.671	0.259
Meld score	12.6 ± 6.3	11.8 ± 6.3	10.8 ± 5.2	0.430	0.242	0.051
Donor Characteristics
Donor age (yr)	37.2 ± 10.2	37.4 ± 11.4	36.9 ± 9.8	0.892	0.558	0.782
Donor BMI (kg/m2)	22.6 ± 3.1	22.7 ± 3.5	23.5 ± 3.6	0.921	0.672	0.691
Donor risk index	1.44	1.41	1.49	0.721	0.322	0.675
Tumor characteristics
Total diameter (cm)	4.1 ± 1.5	4.4 ± 1.8	11.7 ± 4.4	0.307	0.000	0.000
Number (1/2/3/4-5/diffuse)	43/13/2/0/0	54/18/3/15/0	49/17/11/9/34	0.024	0.000	0.000
AFP level (ng/mL)	1361.7 ± 4633.1	1122.4 ± 3764.5	2320.6 ± 10672.4	0.735	0.316	0.520
Overall survival rate				0.036	0.001	0.000
1 yr	94.80%	87.80%	75%
3 yr	91.40%	77.80%	53.30%
5 yr	89.70%	76.60%	50%
Tumor-free survival rate				0.046	0.000	0.000
1 yr	91.40%	85.60%	65.80%
3 yr	86.20%	75.60%	42.50%
5 yr	86.20%	75.60%	41.70%

BMI: Body mass index; LD: Liver disease; HBV-DNA: Hepatitis B virus DNA; DDLT: Deceased donor liver transplantation; LDLT: Living donor liver transplantation; AFP: α-fetoprotein; HCV: Hepatitis C virus.

Table 2 Site of hepatocellular carcinoma recurrence or metastasis after liver transplantation

	Liver	Lung	Bone	Liver + lung	Lung + bone	Intra-abdominal	Other
Milan group	3	1	0	1	0	0	0
In up-to-seven group	8	3	1	4	0	0	0
Out up-to-seven group	16	21	1	9	10	4	3

Other: Lung and brain (1 case), lung and spine liver, lung and bone.