HLA class II associated with outcomes of hepatitis B and C infections

Table 1 Single nucleotide polymorphisms within human leukocyte antigen loci associated with outcomes of hepatitis B virus infection

Ethnic group	Outcome	HLA locus	SNP	Odds	95%CI	HLA haplotype	Odds	Ref.
Japanese	Chronic infection	HLA-DPA1	rs3077	0.56	0.51-0.61			[7]
		HLA-DPB1	rs9277535	0.57	0.52-0.62
						DPA1*0202-DPB1*0501	1.45
						DPA1*0202-DPB1*0301	2.31
						DPA1*0103-DPB1*0402	0.52
						DPA1*0103-DPB1*0401	0.57
Japanese	Chronic infection	HLA-DQ	rs2856718	1.43	1.33-1.54			[8]
			rs7453920	1.66	1.49-1.85
						DQA1*0102-DQB1*0303	19.3
						DQA1*0301-DQB1*0601	5.02
						DQA1*0102-DQB1*0604	0.16
						DQA1*0101-DQB1*0501	0.39
Chinese	Chronic infection	HLA-DPA1	rs2395309	0.71	0.59-0.86			[9]
		HLA-DPA1	rs3077	0.64	0.53-0.78
		HLA-DPA1	rs2301220	0.67	0.56-0.81
		HLA-DPA1	rs9277341	1.77	1.39-2.25
		HLA-DPB1	rs3135021	0.78	0.64-0.94
		HLA-DPB1	rs9277535	0.56	0.47-0.68
		HLA-DPB1	rs10484569	1.60	1.33-1.93
		HLA-DPB1	rs3128917	1.91	1.59-2.30
		HLA-DPB1	rs2281388	1.66	1.38-2.01
		HLA-DPB1	rs3117222	0.51	0.42-0.61
		HLA-DPB1	rs9380343	0.61	0.50-0.73
Indonesian	Vaccine response	HLA-DR	rs3135363	1.59	1.45-1.73			[10]
		HLA-DPB1	rs9277535	0.82	0.71-0.96
		HLA-III	rs9267665	2.13	1.82-2.49
Chinese	HCC	HLA-DQA1/DRB1	rs9272105	1.28	1.22-1.35			[11]
		GRIK1*	rs455804	0.84	0.80-0.89
Japanese, Korean	Chronic infection	HLA-DPA1	rs3077	0.46	0.39-0.54			[12]
		HLA-DPB1	rs9277542	0.50	0.43-0.60
Chinese	Chronic infection	HLA-DPB1	rs9277535	0.60	0.51-0.70			[13]
		HLA-DPA1	rs3077	0.81	0.75-0.95
		HLA-DQ	rs7453920	0.60	0.49-0.73
		HLA-DQ	rs2856718	0.75	0.64-0.89
	HCC	HLA-DQ	rs2856718	0.70	0.59-0.83
		HLA-DPA1	rs3077	0.78	0.67-0.92
Chinese	HCC	HLA-DQ	rs9275319	1.51	1.38-1.66			[14]
		STAT4*	rs7574865

HLA: Human leukocyte antigen; SNP: Single nucleotide polymorphism; HCC: Hepatocellular carcinoma.

Table 2 Single nucleotide polymorphisms within human leukocyte antigen loci associated with outcomes of hepatitis C virus infection

Ethnic group	Outcome	No. of cohorts	HLA locus	SNP	Odds	95%CI	Haplotype	Odds	Ref.
Japanese	HCC	721 HCC vs 2890 HCV-negative controls	MICA	rs2596542	1.34	1.16-1.53			[30]
Japanese	Cirrhosis	682 cirrhosis vs 1045 Chronic hepatitis	C6orf10	rs910049	1.73	1.40-2.15			[31]
			No gene	rs3135363	1.58	1.32-1.90
							DQA1*0601	2.80
							DPB1*0405	1.45

SNP: Single nucleotide polymorphism; HCC: Hepatocellular carcinoma; HLA: Human leukocyte antigen; HCV: Hepatitis C virus.