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World J Gastroenterol. Sep 7, 2013; 19(33): 5395-5401
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5395
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5395
HLA class II associated with outcomes of hepatitis B and C infections
Akihiro Tamori, Norifumi Kawada, Department of Hepatology, Osaka city University Graduate School of Medicine, Osaka 5458585, Japan
Author contributions: Tamori A generated the tables; Tamori A and Kawada N wrote the manuscript.
Correspondence to: Akihiro Tamori, MD, PhD, Associate Professor, Department of Hepatology, Osaka city University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka 5458585, Japan. atamori@med.osaka-cu.ac.jp
Telephone: +81-6-66453811 Fax: +81-6-66461433
Received: April 11, 2013
Revised: June 21, 2013
Accepted: July 30, 2013
Published online: September 7, 2013
Revised: June 21, 2013
Accepted: July 30, 2013
Published online: September 7, 2013
Core Tip
Core tip: Conventional genotyping studies have shown that human leukocyte antigen (HLA) typing was one of the most important host factors with respect to outcomes of hepatitis B and C virus infections. However, the specific HLA locus associated with the outcomes remains unclear. Recently a genome-wide association study for human genotyping demonstrated single nucleotide polymorphisms associated with the outcomes of hepatitis virus infection. Now it has been confirmed that several single nucleotide polymorphisms in both HLA-DP loci were associated with persistent hepatitis B virus infection in Asian populations.