Probiotics improve survival of septic rats by suppressing conditioned pathogens in ascites

Table 1 Comparison of bacterial spectrum and total viable count in ascites between septic model group and probiotics treated group

Group	Bacterial spectrums in ascites	Total viable counts (Log10 cells/mL ascites)
Septic model group	Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Enterococcus avium, Streptococcus viridans, Streptococcus agalactiae, Micrococcus luteus, Enterococcus gallinarum, Enterococcus durans, Enterococcus malodoratus, Streptococcus ferus, Morganella morganii ss morganii, Acinetobacter radioresistens, Streptococcus criceti, Lactobacillus reuteri, Veillonella criceti\ratti, Desulfovibrio fructosivorans, Clostridium oroticum, Lactobacillus bifermentans	9.81 ± 0.67
Probiotics treated group	Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Enterococcus malodoratus, Morganella morganii ss morganii, Enterococcus durans, Streptococcus viridans, Prevotella dentioola, Desulfovibrio fructosivorcms, Bacterorides ovatus, Prevotella nigrescens	5.20 ± 0.57a

Probiotics (1 dose) or vehicle treatment started 6 h later and thereafter administered once a day for 3 d. Samples of ascites were harvested for both anaerobic and aerobic culture. The bacterial spectrum of ascites was lower in probiotics treated group than in septic model group. The total viable counts of bacteria in ascites decreased significantly in probiotics treated group compared with septic model group (n = 18;

^aP < 0.05 vs septic model group).

Table 2 Comparison of bacterial spectrum and total positive rate of hemoculture between septic model group and probiotics treated group

Group	Bacterial spectrums of hemoculture	Total positive rate of hemoculture
Septic model group	Escherichia coli, Staphylococcus aureus, Curtobacterium pusillum, CDC group II-E subgroup A	100%
Probiotics treated group	Escherichia coli, Staphylococcus aureus	33.3%a

Probiotics (1 dose) or vehicle treatment started 6 h later and thereafter administered once a day for 3 d. Samples of blood were harvested for both anaerobic and aerobic culture. The bacterial spectrum of hemoculture was lower in probiotics treated group than in septic model group. The total positive rate of hemoculture decreased significantly in probiotics treated group compared with septic model group (n = 18;

^aP < 0.05 vs septic model group).