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World J Gastroenterol. Jul 7, 2013; 19(25): 4053-4059
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4053
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4053
Probiotics improve survival of septic rats by suppressing conditioned pathogens in ascites
Da-Quan Liu, Qiao-Ying Gao, Hong-Bin Liu, Dong-Hua Li, Shang-Wei Wu, Department of Pharmacology, Institute of Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin 300100, China
Author contributions: Liu DQ and Gao QY contributed equally to this work; Wu SW designed the research; Liu DQ, Gao QY, Li DH and Liu HB performed the research; Liu DQ and Gao QY analysed the data; Liu DQ and Gao QY wrote the paper.
Supported by The Science Foundation of Tianjin Health Bureau, No. 11020
Correspondence to: Shang-Wei Wu, Professor, Department of Pharmacology, Institute of Acute Abdominal Diseases, Tianjin Nankai Hospital, No. 122, Nankai Sanwei Road, Tianjin 300100, China. superldq@yahoo.com.cn
Telephone: +86-22-27435367 Fax: +86-22-27435362
Received: December 27, 2012
Revised: March 28, 2013
Accepted: April 27, 2013
Published online: July 7, 2013
Revised: March 28, 2013
Accepted: April 27, 2013
Published online: July 7, 2013
Core Tip
Core tip: We observed the survival of septic rats treated with different amounts of mixed probiotics. The data indicated that conditioned pathogens such as Escherichia coli and Staphylococcus aureus may be primary pathogens of septic rats in our study. Probiotics improve the survival of septic rats by suppressing the conditioned pathogens.