Differences in HER2 over-expression between proximal and distal gastric cancers in the Chinese population

Table 1 HER2 expression in gastric adenocarcinoma

		n	HER2 score				χ2	P	Univariate analysis
			0	1	2	3			rs	P
Gender	F	244	149	58	19	18	10.106	0.001	-	-
	M	713	366	176	98	73
Age (yr)	≤ 70	682	370	164	82	66	1.347	0.418	-	-
	> 70	275	145	70	35	25
pT	T1	51	28	14	6	3	7.464	0.070	-	-
	T2	145	79	38	19	9
	T3	749	404	179	90	76
	T4	12	4	3	2	3
pN	N0	243	138	60	27	18	13.591	0.335	-	-
	N1	140	63	34	23	20
	N2	205	104	50	31	20
	N3	369	210	90	36	33
pM	M0	935	506	232	114	83	19.984	0.001	0.077	0.020
	M1	22	9	2	3	8			0.105	0.002
pTNM	I	110	59	32	16	3	29.943	0.041	0.039	0.187
	II	267	151	57	30	29
	III	558	296	143	68	51
	IV	22	9	2	3	8
G	Low	324	135	82	50	57	51.360	0.000	-	-
	High	633	380	152	67	34
Lauren	Intestinal	568	256	145	83	84	79.548	0.000	-	-
	Diffuse/mixed	389	253	88	34	7

pTNM: Pathological tumor-node-metastasis; M: Male; F: Female.

Table 2 Comparison of HER2 expression between proximal and distal gastric adenocarcinoma

Group	n	HER2 score				χ2	P
		0	1	2	3
Proximal	513	260	126	72	55	6.691	0.011
Distal	444	255	108	45	36

Table 3 HER2 expression in proximal gastric adenocarcinoma

		n	HER2 score				χ2	P	Univariate analysis
			0	1	2	3			rs	P
Gender	F	108	57	28	13	10	0.884	0.232	-	-
	M	405	203	98	59	45
Age (yr)	≤ 70	371	189	92	48	42	1.647	0.476	-	-
	> 70	142	71	34	24	13
pT	T1	10	4	3	1	2	15.026	0.472	-	-
	T2	61	30	16	11	4
	T3	439	226	107	59	47
	T4	3	0	0	1	2
pN	N0	132	71	34	15	12	6.071	0.524	-	-
	N1	70	31	16	13	10
	N2	124	60	29	22	13
	N3	187	98	47	22	20
pM	M0	503	255	125	70	53	1.959	0.269	-	-
	M1	10	5	1	2	2
pTNM	I	43	20	14	6	3	6.790	0.133	-	-
	II	129	74	26	16	13
	III	331	161	85	48	37
	IV	10	5	1	2	2
G	Low	203	84	52	32	35	19.924	0.000	-0.179	0.000
	High	310	176	74	40	20
Lauren	Intestinal	340	150	85	51	54	39.351	0.000	-0.210	0.000
	Diffuse/mixed	173	110	41	21	1

pTNM: Pathological tumor-node-metastasis; M: Male; F: Female.

Table 4 HER2 expression in distal gastric adenocarcinoma

		n	HER2 score				χ2	P	Univariate analysis
			0	1	2	3			rs	P
Gender	F	136	92	30	6	8	11.510	0.000	0.148	0.000
	M	308	163	78	39	28
Age (yr)	≤ 70	311	181	72	34	24	2.443	0.446	-	-
	> 70	133	74	36	11	12
pT	T1	41	24	11	5	1	3.983	0.131	-	-
	T2	84	49	22	8	5
	T3	310	178	72	31	29
	T4	9	4	3	1	1
pN	N0	111	67	26	12	6	9.645	0.255	-	-
	N1	70	32	18	10	10
	N2	81	44	21	9	7
	N3	182	112	43	14	13
pM	0	432	251	107	44	30	29.728	0.000	0.133	0.000
	1	12	4	1	1	6
pTNM	I	67	39	18	10	0	39.702	0.164	-	-
	II	138	77	31	14	16
	III	227	135	58	20	14
	IV	12	4	1	1	6
G	Low	121	51	30	18	22	31.286	0.000	-0.231	0.000
	High	323	204	78	27	14
Lauren	Intestinal	228	106	60	32	30	40.352	0.000	-0.209	0.000
	Diffuse/mixed	209	143	47	13	6

pTNM: Pathological tumor-node-metastasis; M: Male; F: Female.