Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2013; 19(13): 2019-2027
Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2019
Table 1 microRNA expression in gastric cancer in 2008-2012
Katada et al[29]TaqManmiRNA assays + qRT-PCR42 undifferentiated gastric cancer and controlsmiR-34b miR-34c miR-128amiR-128b, miR-129, miR-148
Guo et al[30]Microarray3 gastric cancers and adjacent normal tissuesmiR-20b, miR-20a, miR-17, miR-106a, miR-18a, miR-21, miR-106b, miR-18b, miR-421, miR-340, miR-19a, miR-658miR-768-3p, miR-378, miR-31, miR-139-5p, miR-195, miR-497, miR-133b,
Yao et al[31]Microarray + qRT-PCR10 gastric cancers and adjacent normal tissuemiR-223, miR-106b, miR-147, miR-34a, miR-130b, miR-106a, miR-18a, miR-17, miR-98, miR-616,miR-181a-2, miR-185, miR-1259, miR-601, miR-196a, miR-221, miR-302f, miR-340, miR-337-3p, miR-520c-3p, miR-575 and miR-138miR-638, miR-378
Luo et al[32]Microarray + qRT-PCR24 gastric cancersMiR-26b, miR-30a-5p, miR-212, miR-320, miR-379, miR-518b, miR-409-3bMiR-9, miR-19b, miR-155, miR-188, miR-197, miR-338, miR-370, miR-383, miR-433, miR-490, miR-503, miR-545, miR-551a, miR-567, miR-575, miR-611, miR-630, miR-649, miR-652
Ueda et al[33]Microarray + qRT-PCR353 (184 gastric cancers 169 controls)miR-181d, miR-181a-1, miR-181a-2, miR-181c, miR-181b-1, miR-181b-2, miR-21, miR-25, miR-92-1, miR-92-2, miR-93, miR-17-5p, miR-106a, miR-20b, miR-135a-1, miR-135a-2, miR-425-5p, miR-106b, miR-20a, miR-19b-1, miR-19b-2miR-148a, miR-148b, miR-375, miR-29b-1, miR-29b-2, miR-29c, miR-152, miR-218-2miR-451, miR-30d
Tsukamoto et al[34]Microarray (470) + qRT-PCR22 gastric cancersmiR-18a, miR-106a, miR-17, miR-146a, miR-93, miR-19a, miR-20a, miR-20b, miR-25, miR-15b, miR-425, miR-92a, miR-194, miR-10a, miR-222, miR-7, miR-106b, miR-320a, miR-21, miR-34a, miR-19b, miR-103, miR-215, miR-192, miR-429, miR-27a, miR-223, miR-23a, miR-107, miR-200b, miR-24, miR-15a, miR-16miR-375, miR-29c, miR-148a, miR-30a-5p, miR-30e-5p, miR-638
Li et al[35]TaqManmiRNA assays + qRT-PCR30 gastric cancer and controlsmiR-223, miR-21, miR-23b, miR-222, miR-25, miR-23a, miR-221, miR-107, miR-103, miR-99a, miR-100, miR-125b, miR-92, miR-146a, miR-214 and miR-191,let-7a, miR-126, miR-210, miR-181b, miR-197, miR-30aa-5p
Carvalho et al[36]Microarray + qRT-PCR76 gastric cancersmiR-582-5p, miR-151-5p, miR-296-5p, miR-30b, miR-513-5p, miR-335, miR-576-5p, miR-219-2-3p, miR-331-5p, miR-889, miR-152, miR-992, miR-93, miR-519c, miR-599, miR-520a-5p, miR-631, miR-550, miR-136, miR-22, miR-515-5p, miR-127-3p, miR-374a, miR-181a, miR-192, miR-532-3p, miR-30d, miR-640, miR-425, miR-92b, miR-501-5p, miR-514, miR-576-3p, miR-519e, miR-149, miR-219-1-3p, miR-424, miR-220, miR-96, miR-218-2, miR-649, miR-215, miR-182, miR-122, miR-524-3p, miR-187, miR-526b, miR-770-5p, miR-545, miR-200b, miR-9, miR-141, miR-579, miR-493, miR-137, miR-216a, miR-503, miR-126, miR-23b, miR-99b, miR-101, miR-323-3p, miR-25, miR-92a-1, miR-429miR-451, miR-502-3p, miR-101 miR-33a, miR-516a-3p/miR-516b
Table 2 Expression of miRNA and area under curve, sensitivity and specificity in serum samples of patients with gastric cancer
GroupSampleMicroRNAAUCMethodSensitivity/specificity (%)
Liu et al[49]61 GC/61 CmiR-378↑0.861qRT-PCR87.5/70.7
Liu et al[50]164 GC/127 C(miR-1, miR-20a, miR-27a, miR-34, miR-423-5P)↑0.879Microarray + qRT-PCR79.3/86.5
Konish et al[51]56 GC/30 CmiR-451↑0.96Microarray + qRT-PCR96.0/100
Song et al[52]82 GC/82 CmiR-221, miR-744 and miR-376c↑NAqRT-PCR82.4/58.8
Zhou et al[53]90 GC/27 CmiR-106a↑0.684Microarray + qRT-PCR48.2/90.2
Wang et al[54]174 GC/39 CmiR-21↑0.81Microarray + qRT-PCR56.7/94.9
Tsujiura et al[55]69 GC/30 CmiR-106b↑0.72Microarray + qRT-PCRNA
miR-106a↑, let-7a↓0.87985.5/80.0
Table 3 Gastric cancer with potential predictive role of miRNAs
Potential predictive role of miRNA
MiRNAs of high expressionMiRNAs of low expression
Short survival timemiRNA-20b, miRNA-150[29], miRNA-142-5p[61], miRNA-375, miRNA-214[62]miRNA-451, let7g1, miRNA-4331[33], miRNA-125-5p3[63]
Lymph node metastasismiRNA-27a[29], miRNA-650[64]miRNA-126[65], miRNA-146a[66], miRNA-148[67], miRNA-218[68], miRNA-335[69], miRNA-429[70]
RelapsemiRNA-375[61], miRNA-4512, miRNA-199-3p2, miRNA-1952[71]miRNA-142-5p[61]
Advanced gastric cancermiRNA-2214[72]miRNA-126[65], miRNA-148a[67], miRNA-218[68]
Invasion, metastasismiRNA-223[35], miRNA-148a[73], miRNA-107[74]miRNA-610[75], miRNA-200b5[76], miRNA-7[77]
Table 4 Expression of miRNA and prediction of the effect of chemotherapy and radiotherapy
Chemosensitivity(let-7g, miR-342, miR-16, miR-181, miR-1, miR-34)1[81]
Chemoresistance(miR-518f, miR-520a, miR-520d, miR-519e, miR-363, miR-517)1[81](miR-196a, miR-200family, miR-338, miR-126, miR-31, miR-98, let-7g, miR-7)2[82] miR-15b, miR-16[83]