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World J Gastroenterol. Apr 7, 2013; 19(13): 2019-2027
Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2019
Clinical application of microRNA in gastric cancer in Eastern Asian area
Ming Gao, Hao Yin, Zhe-Wei Fei
Ming Gao, Zhe-Wei Fei, Department of Surgery, Xin Hua Hospital (Chongming), Shanghai Jiao Tong University School of Medicine, Shanghai 202150, China
Hao Yin, Transplant Section, Department of Surgery, Shanghai Changzheng Hospital, Shanghai 200003, China
Ming Gao, Hao Yin, Department of Surgery, the University of Chicago, Chicago, IL 606372, United States
Author contributions: Gao M, Yin H and Fei ZW contributed equally to this work.
Correspondence to: Zhe-Wei Fei, MD, Department of Surgery, Xin Hua Hospital (Chongming), Shanghai Jiao Tong University School of Medicine, Shanghai 202150, China.
Telephone: +86-21-69692701 Fax: +86-21-69692703
Received: October 12, 2012
Revised: December 16, 2012
Accepted: December 22, 2012
Published online: April 7, 2013

Recent research has shown that microRNA (miRNA), which is involved in almost every step of gastric carcinogenesis, has broad prospective application in diagnosis and therapy of gastric carcinoma. Eastern Asia (South Korea, Japan and China) has the highest incidence of gastric cancer in the world. There were 988  000 new cases of gastric cancer worldwide and 736  000 deaths in 2008. Approximately 60% of the cases of gastric cancer are found in East Asia (mainly China). We herein provide a brief review of the clinical applications of miRNA, which include the following aspects: (1) miRNA may serve as a potential new generation of tumor markers; (2) a complete miRNA expression profile is highly specific, can reflect the evolutionary lineage and differentiation of tumors, and be used to carry out diversity analysis; (3) detecting specific miRNA expression in peripheral blood will become a new method for diagnosis of gastric cancer; (4) miRNA can predict prognosis of gastric cancer; (5) miRNA has predictive value in determining chemotherapy and radiotherapy resistance; and (6) miRNA could be a type of innovative drug. Finally, we focus on assessing the value of miRNA from laboratory to clinical application and the challenges it faces in East Asia.

Keywords: microRNA, Prognosis, Clinical application, Gastric cancer, Eastern Asia