Exogenous carbon monoxide attenuates inflammatory responses in the small intestine of septic mice

Table 1 Histological scoring of granulocyte infiltration and hydropic degeneration in ileum and jejunum tissue stained with hematoxylin-eosin 24 h after cecal ligation and perforation

	Granulocyte infiltration		Hydropic degeneration
	Ileum	Jejunum	Ileum	Jejunum
Sham	0.50 ± 0.12	0.51 ± 0.11	0	0
CLP	1.90 ± 0.46a	1.67 ± 0.12a	1.79 ± 0.34b	1.68 ± 0.28b
CLP + CORM	0.98 ± 0.12c	0.79 ± 0.34c	1.67 ± 0.44	1.72 ± 0.36
CLP + iCORM	1.88 ± 0.30a	1.61 ± 0.17a	1.76 ± 0.67b	1.62 ± 0.45b

For granulocyte infiltration: 0, no granulocyte infiltration; 1, moderate granulocyte infiltration; 2, severe granulocyte infiltration. For hydropic degeneration: 0, no hydropic degeneration; 1, moderate hydropic degeneration; 2, severe hydropic degeneration. Values are presented as mean ± SE.

^aP < 0.05,

^bP < 0.01 vs sham group;

^cP < 0.05 vs cecal ligation and perforation (CLP) group. CORM: Carbon monoxide-releasing molecule; iCORM: Inactivated-carbon monoxide-releasing molecule.