Different risk factors influence peptic ulcer disease development in a Brazilian population

Table 1 Additive logistic regression models to evaluate the contribution of age and sex among patients who underwent gastroscopy (n_total = 1466)

Factor		CG	DU	GU
Overall	n (+)	1060	88	75
	χ2 (v = 2)	2.14	8.99	30.51
	P	0.3423	0.01121	< 0.00011
	β0	0.738	-2.724	-4.836
Age	β1	0.003	-0.007	0.023
	SE	0.0034	0.0065	0.0073
	P	0.3511	0.2699	0.00171
	OR	1.003	0.993	1.023
	CI-	0.997	0.980	1.009
	CI+	1.010	1.006	1.038
Sex	β2	0.124	0.622	1.125
	SE	0.1102	0.2256	0.2636
	P	0.2598	0.00581	< 0.00011
	OR	1.132	1.863	3.079
	CI-	0.912	1.197	1.837
	CI+	1.405	2.899	5.162

¹Significant effects. n_total: Number of investigated cases; n (+): Number of positive cases; CG: Chronic gastritis; DU: Duodenal ulcer; GU: Gastric ulcer; OR: Odds ratios; CI: Confidence intervals. Critical P-values were adopted after a Bonferroni correction for the number of similar tests: P = 0.05/3 = 0.0167 for overall models; and P = 0.05/2 = 0.025 for each independent factor.

Table 2 Logistic regression models to evaluate the contribution of age, sex, chronic gastritis, duodenal ulcer

Factor		Atrophy	Metaplasia	H. pylori	m1	m2
Overall	ntotal	1020	1094	1045	668	668
	n (+)	243	140	539	251	233
	χ2	35.18	71.67	47.83	9.88	5.85
	v	1	1	2	1.00	1
	P	< 0.00011	< 0.00011	< 0.00011	0.00171	0.0156
	β0	-2.614	-4.733	0.881	-0.589	-0.038
Age	β1	0.027	0.050	-0.018	-	-0.012
	SE	0.0047	0.0063	0.0039	-	0.0048
	P	< 0.00011	< 0.00011	< 0.00011	-	0.0162
	OR	1.027	1.051	0.983	-	0.989
	CI-	1.018	1.038	0.975	-	0.979
	CI+	1.037	1.064	0.990	-	0.998
DU	β2	-	-	1.255	0.857	-
	SE	-	-	0.2702	0.2739	-
	P	-	-	< 0.00011	0.00181	-
	OR	-	-	3.506	2.356	-
	CI-	-	-	2.065	1.377	-
	CI+	-	-	5.954	4.031	-

¹Significant effects after Bonferroni correction. n_total: Number of investigated cases; n (+): Number of positive cases; CG: Chronic gastritis; DU: Duodenal ulcer; OR: Odds ratios; CI: Confidence intervals; H. pylori: Helicobacter pylori.

Table 3 Additive logistic regression models to evaluate the contribution of age, sex, chronic gastritis, duodenal ulcer and gastric ulcer disease

Factor		Atrophy	Metaplasia	H. pylori	m1	m2
Overall	ntotal	1020	1094	1045	668	668
	n(+)	243	140	539	251	233
	χ2(v = 5)	64.34	78.63	50.14	13.46	10.64
	P	< 0.00011	< 0.00011	< 0.00011	0.01941	0.05911
	β0	-24.434	-6.616	0.832	-1.448	-0.225
Age	β1	0.029	0.051	-0.017	-0.003	-0.012
	SE	0.0047	0.0064	0.0039	0.0048	0.0048
	P	< 0.00011	< 0.00011	< 0.00011	0.5646	0.01391
	OR	1.030	1.052	0.983	0.997	0.988
	CI-	1.020	1.039	0.975	0.988	0.979
	CI+	1.039	1.065	0.990	1.007	0.998
Sex	β2	0.064	0.101	-0.179	0.035	-0.327
	SE	0.1530	0.190	0.1283	0.1635	0.1659
	P	0.6775	0.5969	0.1629	0.8320	0.0485
	OR	1.066	1.106	0.836	1.035	0.721
	CI-	0.790	0.761	0.650	0.752	0.521
	CI+	1.438	1.607	1.075	1.426	0.998
CG	β3	21.676	1.807	0.135	0.985	0.378
	SE	> 100	0.8427	0.4533	0.5742	0.5710
	P	0.9978	0.0320	0.7661	0.0863	0.5082
	OR	> 100	6.090	1.144	2.678	1.459
	CI-	0.000	1.168	0.471	0.869	0.477
	CI+	> 100	31.761	2.782	8.253	4.469
DU	β4	0.552	-0.313	1.283	0.856	-0.175
	SE	0.2658	0.3972	0.2712	0.2771	0.2931
	P	0.0377	0.4308	< 0.00011	0.00201	0.5496
	OR	1.737	0.731	3.608	2.353	0.839
	CI-	1.032	0.336	2.120	1.367	0.472
	CI+	2.924	1.593	6.139	4.050	1.491
GU	β5	-0.065	0.483	-0.032	0.419	0.267
	SE	0.3825	0.4260	0.3185	0.3927	0.4038
	P	0.8660	0.2567	0.9200	0.2863	0.5083
	OR	0.938	1.621	0.969	1.520	1.306
	CI-	0.443	0.704	0.519	0.704	0.592
	CI+	1.984	3.736	1.808	3.282	2.883

¹Significant effects. n_total: Number of investigated cases; n (+): Number of positive cases; CG: Chronic gastritis; DU: Duodenal ulcer; GU: Gastric ulcer; OR: Odds ratios; CI: Confidence intervals; H. pylori: Helicobacter pylori. Critical P-values were adopted after a Bonferroni correction for the number of similar tests: P = 0.05/5 = 0.01 for overall model and for each independent factor.