Brief Article
Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 7, 2012; 18(37): 5276-5282
Published online Oct 7, 2012. doi: 10.3748/wjg.v18.i37.5276
Table 1 Genotype and allele frequency of the -2922(C)2-3 and -1198(C/G) allele in Mexican American alcoholics and nonalcoholics n (%)
Groups-2922(C)2-3 allele
-1198(C/G) allele
Genotype
Allele frequency
TotalGenotype
Allele frequency
Total
(C)2/(C)2(C)2/(C)3(C)3/(C)3(C)3C/CC/GG/GC
Non-alcoholic119 (34.4)132 (38.2)95 (27.5)322 (46.5)34676 (23.5)146 (46.1)98 (30.3)298 (46.6)320
Alcoholic87 (23.3)192 (51.3)95 (25.4)a382 (51.1)37448 (13.9)176 (50.9)122 (35.3)a272 (39.3)b346
Table 2 Genotype and allele frequency of the -2922(C)2-3 allele in Mexican American alcoholics and non-alcoholics controlling for confounding effect of smokers and obesity n (%)
GroupsGenotype
Allele frequency
(C)2/(C)2(C)2/(C)3(C)3/(C)3(C)3
Non-alcoholic
BMI < 30 kg/m2 (213)73 (34.3)78 (36.6)62 (29.1)202 (47.4)
BMI ≥ 30 kg/m2 (122)41 (33.6)48 (39.3)33 (27.0)114 (46.7)
Alcoholic
BMI < 30 kg/m2 (198)37 (18.7) 107 (54.0)54 (27.3)a215 (54.3)b
BMI ≥ 30 kg/m2 (146)37 (21.5)74 (50.7)35 (25.9)144 (49.3)
Non-alcoholic
Non-smokers (282)100 (35.5) 101 (35.8)81 (28.7)263 (46.6)
Smokers (59)17 (28.8)29 (49.2)13 (22.0)55 (46.6)
Alcoholic
Non-smokers (197)49 (24.9)88 (44.7)60 (30.5)c  208 (52.8)
Smokers (177)38 (21.5) 104 (58.8)35 (19.8)d174 (49.2)
Table 3 Genotype and allele frequency of the -1198(C/G) allele in Mexican American alcoholics and non-alcoholics controlling for confounding effect of smoking and obesity n (%)
GroupsGenotype
Allele frequency
C/CC/GG/GC
Non-alcoholic
BMI < 30 kg/m2 (199)54 (27.1)81 (40.7)64 (32.2)189 (47.5)
BMI ≥ 30 kg/m2 (115)21 (18.3)62 (53.9)32 (27.8)104 (45.2)
Alcoholic
BMI < 30 kg/m2 (181)26 (14.4)92 (50.8)63 (34.8)a144 (39.8)b
BMI ≥ 30 kg/m2 (136)18 (13.2)73 (53.7)45 (33.1)109 (40.1)
Non-alcoholic
Non-smokers (265)61 (23.0)122 (46.0)82 (30.9)244 (46.0)
Smokers (55)15 (18.3)24 (53.9)16 (27.8)54 (49.1)
Alcoholic
Non-smokers (185)27 (14.6)90 (48.6)68 (36.8)144 (38.9)c
Smokers (161)21 (13.0)86 (53.4)54 (33.5)d128 (39.7)