GABA stimulates human hepatocellular carcinoma growth through overexpressed GABAA receptor theta subunit

Table 1 Cell cycle of HepG-2/Si-Mock and HepG-2/Si-1 (mean ± SD, n = 3)

	Si-1	Si-Mock
G0/G1 (%)	53.95 ± 3.22	49.95 ± 3.56
G2/M (%)	22.38 ± 2.79	21.61 ± 3.83
S (%)	24.29 ± 3.32	28.74 ± 3.85a

^aP < 0.05 vs Si-1.

Table 2 Cell cycle of HepG-2 treated with gamma-aminobutyric acid at serial concentrations (mean ± SD, n = 3, μmol/L)

	0	1	10	20	40	60
G0/G1 (%)	40.9 ± 2.92	39.6 ± 2.73	33.8 ± 2.79	31.7 ± 2.56	30.2 ± 2.17	47.2 ± 2.93
G2/M (%)	18.1 ± 0.84	19.8 ± 0.97	20.7 ± 0.85	21.3 ± 0.79	20.3 ± 1.18	18.5 ± 1.23
S (%)a	31.0 ± 1.89	30.6 ± 1.94	35.5 ± 2.28	37.0 ± 2.17	39.5 ± 2.34	34.3 ± 2.02

^aP < 0.05 vs HepG-2 treated with gamma-aminobutyric acid.

Table 3 Cell cycle of HepG-2/Si-Mock and HepG-2/Si-1 treated with or without gamma-aminobutyric acid at concentration of 40 μmol/L (mean ± SD, n = 3)

	Si-Mock	Si-Mock + GABA	Si-1	Si-1 + GABA
G0/G1 (%)	49.95 ± 3.16	46.21 ± 2.98	53.95 ± 2.62	48.68 ± 2.49
G2/M (%)	21.61 ± 3.43	20.82 ± 2.43	22.38 ± 2.19	21.45 ± 2.26
S (%)	28.74 ± 3.35	33.64 ± 3.76a	24.29 ± 2.72b	27.43 ± 1.95

^aP < 0.05,

^bP < 0.01 vs Si-Mock.