Reduced Popdc3 expression correlates with high risk and poor survival in patients with gastric cancer

Table 1 Patient characteristics and Popeye domain containing 3 expression in gastric cancer n (%)

Clinical parameters		Popdc3
	n	Low	High	χ2	Pvalue
Age (yr)
< 50	105	72 (68.6)	33 (31.4)
≥ 50	201	156 (77.6)	45 (22.4)	2.968	0.085
Gender
Male	199	148 (74.4)	51 (25.6)
Female	107	80 (74.8)	27 (25.2)	0.006	0.940
Size (cm)
< 5	154	120 (77.9)	34 (22.1)
≥ 5	152	108 (71.1)	44 (28.9)	1.901	0.168
Histology
Papillary adenocarcinoma	8	5 (62.5)	3 (37.5)
Tubular adenocarcinoma	209	151 (72.2)	58 (27.8)
Mucinous adenocarcinoma	52	42 (80.8)	10 (19.2)
Signet ring cell carcinoma	37	30 (81.1)	7 (18.9)	3.084	0.379
Histologic differentiation
Well	17	13 (76.5)	4 (23.5)
Moderate	100	67 (67)	33 (33)
Poor	177	140 (79.1)	37 (20.9)
Undifferentiated	12	8 (66.7)	4 (33.3)	4.439	0.109
Invasion depth
T1	24	10 (41.7)	14 (58.3)
T2	63	32 (50.8)	31 (49.2)
T3	181	149 (82.3)	32 (17.7)
T4a	28	24 (85.7)	4 (14.3)
T4b	10	7 (70.0)	3 (30.0)	48.566	< 0.0001
Regional lymph nodes
N0	163	94 (57.7)	69 (42.3)
N1	41	39 (95.1)	2 (4.9)
N2	54	49 (90.7)	5 (9.3)
N3a	20	14 (70.0)	6 (30.0)
N3b	27	19 (70.4)	8 (29.6)	52.504	< 0.0001
Distant metastasis
M0	274	197 (71.9)	77 (28.1)
M1	32	31 (96.9)	1 (3.1)	9.412	0.002
TNM stages
I	73	30 (41.1)	43 (58.9)
II	109	81 (74.3)	28 (25.7)
III	92	86 (93.5)	6 (6.5)
IV	32	31 (96.9)	1 (3.1)	70.624	< 0.0001

TNM: Tumor, nodes, metastasis; Popdc3: Popeye domain containing 3.

Table 2 Multivariate analysis for disease-related deaths (Cox regression model)

Variables	Pvalue	Hazard ratio	95% CI
Popdc3	< 0.0001	0.193	0.133-0.282
Gender	0.016	1.388	1.063-1.814
Regional lymph nodes	< 0.0001	1.344	1.156-1.564
Distant metastasis	< 0.0001	11.591	6.131-21.915
TNM stages	0.002	1.486	1.159-1.905

CI: Confidence interval; TNM: Tumor, nodes, metastasis; Popdc3: Popeye domain containing 3.

Table 3 Survival estimates and 95% confidence intervals for disease-related deaths

Groups	Median survival (mo)	1-yr survival rate (%)	3-yr survival rate (%)	χ2	Pvalue
Low Popdc3 expression	23 (21.20-24.79)	175 (76.75)	38 (16.7)
High Popdc3 expression	55 (53.51-56.48)	69 (88.46)	66 (84.6)	145.095	< 0.0001
Stage I-II with low Popdc3 expression	29 (21.00-38.00)	97 (87.39)	44 (39.64)
Stage I-II with high Popdc3 expression	55 (45.00-61.00)	65 (91.55)	65 (91.55)	104.741	< 0.0001
Stage III-IV with low Popdc3 expression	15 (10.00-21.50)	78 (66.67)	12 (10.26)
Stage III-IV with high Popdc3 expression	30 (12.00-44.00)	4 (57.14)	3 (42.86)	5.93	0.015

Popdc3: Popeye domain containing 3.