Metastasis-associated protein 1 induces VEGF-C and facilitates lymphangiogenesis in colorectal cancer

Table 1 Correlation of metastasis-associated protein 1 and vascular endothelial growth factor-C immunohistochemistry with clinicopathological parameters of patients

Parameters of patients		MTA1			VEGF-C
	n	High	Low	P value	High	Low	P value
Age
≤ 60	34	11	23	0.805	16	18	0.552
> 60	47	14	33		19	28
Gender
Male	45	17	28	0.132	21	24	0.483
Female	36	8	28		14	22
Tumor Size
≤ 5 cm	46	10	36	0.042	18	28	0.395
> 5 cm	35	15	20		17	18
Location
Colon	47	16	31	0.467	18	29	0.294
Rectum	34	9	25		17	17
Depth of invasion
T1 + T2	15	3	12	0.313	4	11	0.152
T3 + T4	66	22	44		31	35
Differentiation
Well, moderately	59	15	44	0.083	24	35	0.451
Poorly	22	10	12		11	11
Dukes stages
A + B	41	8	33	0.004	10	31	0.001
C + D	40	17	23		25	15
Lymph node metastasis
Yes	40	17	23	0.025	24	16	0.003
No	41	8	33		11	30

MTA1: Metastasis-associated protein 1; VEGF-C: Vascular endothelial growth factor-C.

Table 2 Correlation between expression levels of metastasis-associated protein 1 and vascular endothelial growth factor-C in human colorectal cancer

MTA1a	VEGF-Ca
	Score 0	Score 1	Score 2	Score 3
Score 0	101	8	5	2
Score 1	8	13	6	4
Score 2	4	2	8	1
Score 3	0	1	3	6

^aP = 0.001, r = 0.371, Spearman's coefficient of correlation.

¹Number of cases. MTA1: Metastasis-associated protein 1; VEGF-C: Vascular endothelial growth factor-C .