Liver transplantation for hepatocellular carcinoma on cirrhosis: Strategies to avoid tumor recurrence

Table 1 Accuracy of imaging techniques in the pre-transplant staging of hepatocellular carcinoma

Author, yr, center	No. of pts	Accuracy in detecting No. of nodules (%)	Accuracy in detecting diameter of nodules (%)	Accuracy in assessing Milan criteria (%)
Yao FY, 2001, San Francisco	70	75	62-80	nr
Sotiropoulus GC, 2005, Essen	70	34	14	60
Shah SA, 2006, Toronto	118	75	78	57
Grasso A, 2006, London	74	80	80	nr

pts: Patients; nr: Not reported.

Table 2 Proposed criteria for liver transplantation in patients with hepatocellular carcinoma

Author, yr, center	No. of pts	Selection criteria	Survival
Mazzaferro V, 1996, Milan	48	1 nodule ≤ 5 cm or	83% (4-yr RF)
		≤ 3 nodules ≤ 3 cm
Yao FY, 2001, San Francisco	70	1 HCC ≤ 6.5 cm or ≤ 3 HCC ≤ 4.5 cm with cumulative diameter ≤ 8 cm	75.2% (5-yr overall)
Toso C, 2008, Edmonton	288	Total HCC volume ≤ 115 cm3	80% (5-yr overall)
Mazzaferro V, 2009, multicenter study	1556	No. of HCC nodules + maximum diameter (cm) ≤ 7	71% (5-yr overall) if MVI absent

pts: Patients; RF: Recurrence-free; HCC: Hepatocellular carcinoma; MVI: Microvascular tumor invasion.