Cho HC, Paik SW, Kim YJ, Choi MS, Lee JH, Koh KC, Yoo BC, Son HJ, Kim SW. Seroprevalence of anti-HAV among patients with chronic viral liver disease. World J Gastroenterol 2011; 17(2): 236-241 [PMID: 21245998 DOI: 10.3748/wjg.v17.i2.236]
Corresponding Author of This Article
Seung Woon Paik, MD, Professor, Division of Gastroenterology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea. sw.paik@samsung.com
Article-Type of This Article
Brief Article
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World J Gastroenterol. Jan 14, 2011; 17(2): 236-241 Published online Jan 14, 2011. doi: 10.3748/wjg.v17.i2.236
Table 1 Patient characteristics
Variable
n (%)
Mean age (yr, range)
49 ± 9 (20-80)
Gender
Female
272 (27.59)
Male
714 (72.41)
Chronic liver disease
Chronic viral hepatitis B
506 (51.32)
Chronic viral hepatitis C
23 (2.33)
HBV related liver cirrhosis
450 (45.64)
HCV related liver cirrhosis
7 (0.71)
Place of residence
Seoul
389 (39.45)
Gyeonggi-do
274 (27.79)
Metropolitan cities
101 (10.24)
Other provinces
223 (22.62)
Prevalence of IgG anti-HAV
854 (86.61)
Table 2 Prevalence of IgG anti-hepatitis A virus in patients with hepatitis B virus vs those with hepatitis C virus infection n (%)
Age (yr)
Anti-HAV/HBV
Anti-HAV/HCV
20-30
3/43 (6.98)
0
31-40
58/112 (51.79)
0/2 (0)
41-50
325/351 (92.59)
6/7 (85.71)
51-60
378/387 (97.67)
12/12 (100)
≥ 61
63/63 (100)
9/9 (100)
Table 3 Prevalence of IgG anti-hepatitis A virus according to gender, the status of liver disease and the place of residence
Characteristics
Anti-HAV positivity, n (%)
P value
Sex
0.049
Male
609/714 (85.29)
Female
245/272 (90.07)
Status of liver disease
< 0.001
Chronic viral hepatitis
425/529 (80.34)
Liver cirrhosis
429/457 (93.87)
Place of residence
< 0.001
Seoul
311/389 (79.95)
Gyeonggi-do
241/274 (87.96)
Metropolitan cities
96/101 (95.05)
Other provinces
206/223 (92.38)
Table 4 Factors affecting seropositivity for IgG anti-hepatitis A virus on the multivariable analysis
Characteristics
Anti-HAV positivity, n (%)
OR (95% CI)
P value
Age (≥ 40 yr)
809/852 (94.95)
33.44 (20.14-55.52)
< 0.001
Female
245/272 (90.07)
2.07 (1.16-3.71)
0.014
Etiology
0.487
HBV
827/956 (86.51)
1
HCV
27/30 (90)
0.61 (0.15-2.47)
Status of liver disease
0.075
Chronic viral hepatitis
425/529 (80.34)
1
Liver cirrhosis
429/457 (93.87)
1.64 (0.95-2.82)
Place of residence
0.035
Seoul
311/389 (79.95)
1
Gyeonggi-do
241/274 (87.96)
1.51 (0.86-2.66)
0.153
Metropolitan cities
96/101 (95.05)
4.11 (1.37-12.35)
0.012
Other provinces
206/223 (92.38)
1.84 (0.93-3.65)
0.080
Citation: Cho HC, Paik SW, Kim YJ, Choi MS, Lee JH, Koh KC, Yoo BC, Son HJ, Kim SW. Seroprevalence of anti-HAV among patients with chronic viral liver disease. World J Gastroenterol 2011; 17(2): 236-241