Risk factors for residual tumor after resection of hepatocellular carcinoma

doi:10.3748/wjg.v17.i14.1889

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 14

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2372)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-2) series.

Item

Count

PDF

215

HTML

1891

Figures (1-2)

135

Tables (1-2)

131

Sum=2372

Apr 14, 2011 (publication date) through Apr 18, 2024

Times Cited of This Article

Times Cited (1)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Apr 14, 2011; 17(14): 1889-1894
Published online Apr 14, 2011. doi: 10.3748/wjg.v17.i14.1889

Table 1 Main characteristics of 766 hepatocellular carcinoma patients with (Group 1) or without (Group 2) residual tumor n (%)

Characteristics		Group 1	Group 2	χ²	P-value
Sex	Female	11 (17.46)	96 (13.66)	0.6964	> 0.05
Sex	Male	52 (82.54)	607 (86.34)	0.6964	> 0.05
Age (yrs)	≤ 30	3 (4.76)	17 (2.42)	1.2490	> 0.05
	30-60	48 (76.19)	549 (78.09)
	> 60	12 (19.05)	137 (19.49)
Child-Pugh score	Class A	62 (98.41)	692 (98.44)	0.0002	> 0.05
Child-Pugh score	Class B	1 (1.59)	11 (1.56)	0.0002	> 0.05
Cirrhotic nodule	No	7 (11.11)	121 (17.21)	1.5462	> 0.05
Cirrhotic nodule	Yes	56 (88.89)	582 (82.79)	1.5462	> 0.05
HBsAg	Negative	8 (12.70)	90 (12.80)	0.0006	> 0.05
HBsAg	Positive	55 (87.30)	613 (87.20)	0.0006	> 0.05
ALT level¹, U/L	≤ 80	57 (90.48)	621 (88.34)	0.2605	> 0.05
ALT level¹, U/L	> 80	6 (9.52)	82 (11.66)	0.2605	> 0.05
GGT level¹, U/L	≤ 60	24 (38.10)	367 (52.20)	4.6062	< 0.05
GGT level¹, U/L	> 60	39 (61.90)	336 (47.80)	4.6062	< 0.05
AFP level, ng/mL	≤ 20	8 (12.70)	259 (36.84)	16.0745	< 0.01
	20-400	20 (31.75)	192 (27.31)
	≥ 400	35 (55.56)	252 (35.85)
Tumor size², cm	≤ 2	3 (4.76)	82 (11.66)	23.3257	< 0.01
	2-5	19 (30.16)	333 (47.37)
	5-8	15 (23.81)	166 (23.61)
	> 8	26 (41.27)	122 (17.35)
Capsule	complete/present	31 (49.21)	390 (55.48)	0.9183	> 0.05
Capsule	incomplete/absent	32 (50.79)	313 (44.52)	0.9183	> 0.05
Microvascular invasion	No	30 (47.62)	472 (67.14)	9.7556	< 0.01
Microvascular invasion	Yes	33 (52.38)	231 (32.86)	9.7556	< 0.01
Tumor number	solitary nodule	49 (77.78)	597 (84.92)	3.8413	> 0.05
	2 nodules	13 (20.63)	86 (12.23)
	3 nodules	1 (1.59)	20 (2.84)
Cell differentiation grade	GradeI-II	41 (65.08)	506 (71.98)	1.3475	> 0.05
Cell differentiation grade	Grade III-IV	22 (34.92)	197 (28.02)	1.3475	> 0.05
pTNM staging	Stage I	21 (33.33)	409 (58.18)	15.1735	< 0.01
	Stage II	34 (53.97)	250 (35.56)
	Stage III A	8 (12.70)	44 (6.26)
BCLC classification	Stage A	49 (77.78)	607 (86.34)	3.4501	> 0.05
BCLC classification	Stage B	14 (22.22)	96 (13.66)	3.4501	> 0.05

¹ALT value (normal value, ≤ 75 IU/L), using 80 IU/L as cutoff, and GGT level > 60 IU/L (normal range, 11–50 IU/L) was used as the elevated level [7].

²Tumor size: Diameter of the largest nodule was used as tumor size when multiple.

Table 2 Multivariate stepwise logistic regression analysis of independent risk factors related to residual tumor

Risk factor		Coefficient	OR (95% CI)	P-value
AFP level (ng/mL)	≤ 20 = 0	0.52	1.68 (1.20-2.36)	< 0.01
	20-400 = 1
	> 400 = 2
Tumor size (cm)	≤ 2 = 0	0.55	1.73 (1.29-2.31)	< 0.01
	2-5 = 1
	5-8 = 2
	> 8 = 3
Microvascular invasion	No = 0	0.65	1.91 (1.12-3.24)	0.02
Microvascular invasion	Yes = 1	0.65	1.91 (1.12-3.24)	0.02

Citation: Chen XH, Zhang BH, Xin Y, Ren ZG, Fan J, Qiu SJ, Zhou J. Risk factors for residual tumor after resection of hepatocellular carcinoma. World J Gastroenterol 2011; 17(14): 1889-1894
URL: https://www.wjgnet.com/1007-9327/full/v17/i14/1889.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i14.1889