Brief Article
Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 14, 2011; 17(14): 1831-1835
Published online Apr 14, 2011. doi: 10.3748/wjg.v17.i14.1831
Table 1 Characteristics of granulocyte-monocyte apheresis treated patients: Demographic and clinical data
SexF/M39/30
Age (yr)mean (range)42.36 (27-75)
Duration of disease (mo)mean (range)41.34 (12-262)
Location of diseaseLeft side/pancolitis47/22
Steroid courseDependent/resistant49/20
CAImean (range)9.10 (6-13)
ESR (mm/h)mean (range)33.09 (2-20)
CRP (mg/dL)mean (range)2.04 (0.3-7.3)
WBC 103mean (range)10.69 (5.7-14)
Table 2 Univariate analysis of predictive factors of clinical response to granulocyte-monocyte apheresis: Age, White blood cells, erythrocyte sedimentation rate and clinical activity index score, C reactive protein, location duration of disease at baseline and use of immunosuppressant (mean ± SD)
Responders (n = 40)Non responders (n = 29)P-value
Age (yr)42.7 ± 13.841.9 ± 6.60.774
WBC 10310.2 ± 2.711.2 ± 2.20.106
ESR (mm/h)30.6 ± 13.538.4 ± 12.50.017
CAI8.6 ± 2.19.7 ± 2.20.039
CRP (mg/dL)1.2 ± 1.21.4 ± 1.40.526
Location of disease (left side/pancolitis)28/1219/100.795
Duration of disease (yr)1160.581
Use of immunosuppressant5150.601
Table 3 Multivariate analysis of predictive factors of clinical response to granulocyte-monocyte apheresis: Steroid course and clinical activity index score at baseline
Independent variablesOR95% CIWaldP-value
Steroid course0.3900.176-0.8655.3610.016
4 < CAI < 80.7700.425-1.3943.7470.028
CRP (mg/dL)0.9080.381-2.1660.0470.828
ESR (mm/h)0.9650.491-1.8960.0110.917
Location of disease (Left side/pancolitis)0.8220.462-1.4620.4460.504
Duration of disease > 120 mo1.0890.485-2.4660.0430.836