Metabolic investigations in patients with hepatitis B and C

Table 1 Clinical data of patients with HBV and HCV (mean ± SE)

	Controls	Hepatitis B	Hepatitis C
Age (yr)	40.5 ± 1.5	43.5 ± 1.8	42.8 ± 1.3
Sex (M/F)	35/15	33/17	36/14
Albumin (g/dL)	3.68 ± 0.083	3.20 ± 0.079c	3.07 ± 0.090c
Total protein (g/dL)	8.40 ± 1.23	6.84 ± 0.80b	6.74 ± 0.82c
Glucose (F) (mg/dL)	81.56 ± 1.47	77.94 ± 1.27a	76.56 ± 1.43a

^aP < 0.05,

^bP < 0.01,

^cP < 0.001 vs controls. HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Table 2 Metabolic parameters measured in plasma of HBV/HCV patients and healthy controls (mean ± SE, mg/dL)

	Controls	Hepatitis B	Hepatitis C
Urea	28.84 ± 0.89	24.28 ± 0.779c	22.06 ± 0.832c
Creatinine	0.73 ± 0.021	0.59 ± 0.015a	0.57 ± 0.013c
Uric acid	3.68 ± 0.069	5.13 ± 0.22b	5.02 ± 0.169c
Cholesterol	172.44 ± 3.03	127.56 ± 1.70c	124.24 ± 1.77c
HDL	30.42 ± 0.57	27.96 ± 0.36b	27.44 ± 0.385c
LDL	112.34 ± 2.98	97.88 ± 1.87c	95.16 ± 1.81c
Triglycerides	96.00 ± 4.33	95.30 ± 3.76a	84.12 ± 1.51b
Mg	19.76 ± 0.59	20.49 ± 0.70	20.94 ± 0.82
Fe	2.93 ± 0.14	3.14 ± 0.05b	3.22 ± 0.07b
Zn	4.16 ± 0.12	3.26 ± 0.11c	3.38 ± 0.13b
Cu	2.03 ± 0.05	2.08 ± 0.02a	2.11 ± 0.03
Antioxidant activity	1.52 ± 0.05	0.37 ± 0.05c	0.43 ± 0.05c

^aP < 0.05,

^bP < 0.01,

^cP < 0.001 vs controls.

Table 3 Enzyme activity in blood serum of patients with Hepatitis B/C and healthy controls

	Controls	Hepatitis B	Hepatitis C
ALK (IU/L)	115.64 ± 3.98	145.82 ± 8.47b	120.34 ± 5.84
ALT or s-GPT (mU/mL)	22.34 ± 1.67	59.24 ± 3.28c	89.60 ± 6.41c
CPK (IU/L)	106.56 ± 6.52	86.10 ± 3.34a	101.88 ± 3.99
LDH (U/L)	331.06 ± 9.13	353.72 ± 9.37a	395.48 ± 11.16c
AST or s-GOT (IU/L)	18.86 ± 0.71	40.88 ± 1.44c	45.80 ± 1.95c
ALT/AST ratio	1.13 ± 0.071	1.56 ± 0.083c	1.94 ± 0.11c

^aP < 0.05,

^bP < 0.01,

^cP < 0.001 vs controls.