Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients

Table 1 Comparison of clinical parameters between anti-nuclear envelope antibody positive and anti-nuclear envelope antibody negative patients (mean ± SD) n (%)

	ANEA		P value
	Positive	Negative
Patients	69 (46.9)	78 (53.1)
Age (yr)	59.3 ± 11.8	59.1 ± 10.1	0.330
AMA titer ≤ 1:160/> 1:1601	35 (50.7)/34 (49.3)	56 (71.8)/22 (28.2)	0.001
Stage I-II/stage III-IV	39 (56.5)/30 (43.5)	58 (74.4)/20 (25.6)	0.005
Alive/dead	51 (77.3)/15 (22.7)	66 (86.8)/10 (13.2)	0.162
Survival	91.7 ± 50.7	101.8 ± 55	0.043
Mayo risk score	5.19 ± 1.8	5.04 ± 1.3	0.239

¹1/160 is the median antimitochondrial antibodies titer. ANEA: Anti-nuclear envelope antibody.

Table 2 Comparison of histological parameters between anti-nuclear envelope antibody positive and anti-nuclear envelope antibody negative patients n (%)

	Histological parameters		P value
	ANEA positive (n = 69)	ANEA negative (n = 78)
Fibrosis
1	10 (22.7)	22 (40.7)	0.008
2	17 (38.6)	22 (40.7)
3	17 (38.6)	10 (18.6)
Portal inflammation
1	8 (18.2)	22 (40.7)	0.008
2 + 3	36 (81.8)	32 (59.3)
Interface hepatitis
0 + 1	16 (36.4)	31 (57.4)	0.019
2 + 3	28 (63.6)	23 (42.6)
Intralobular inflammation
0	11 (25)	9 (16.7)	0.359
1	19 (43.2)	35 (64.8)
2	14 (31.8)	10 (18.5)
Proliferation of bile ductules
0	12 (27.3)	25 (46.3)	0.027
1	32 (72.7)	29 (53.7)
Epithelioid granuloma
0	31 (70.5)	39 (72.2)	0.425
1	13 (29.5)	15 (27.8)

ANEA: Anti-nuclear envelope antibody.

Table 3 Comparison of histological parameters between anti-nuclear envelope antibody positive, gp210 negative, and anti-nuclear envelope antibody negative patients n (%)

	Histological parameters		P value
	Gp210 negative (n = 38)	ANEA negative (n = 78)
Fibrosis
1	7 (25.0)	22 (40.7)	0.009
2	8 (28.6)	22 (40.7)
3	13 (48.4)	10 (18.6)
Portal inflammation
1	5 (17.9)	22 (40.7)	0.018
2 + 3	23 (82.1)	32 (59.3)
Interface hepatitis
0 + 1	10 (35.7)	31 (57.4)	0.032
2 + 3	18 (64.3)	23 (42.6)
Intralobular inflammation
0	8 (28.6)	9 (16.7)	0.274
1	14 (50.0)	35 (64.8)
2	6 (21.4)	10 (18.5)
Proliferation of bile ductules
0	7 (25.0)	25 (46.3)	0.031
1	21 (75.0)	29 (53.7)
Epithelioid granuloma
0	19 (67.9)	39 (72.2)	0.342
1	9 (32.1)	15 (27.8)

ANEA: Anti-nuclear envelope antibody.