Body composition changes after transjugular intrahepatic portosystemic shunt in patients with cirrhosis

Table 1 Modification of values studied in 21 patients (mean ± SD)

Variable	Basal Pre-TIPS	After 52 wk	P
HVPG (mmHg)	15.8 ± 4.8	6.0 ± 2.1	< 0.001
Bilirubin (mg/dL)	1.26 ± 1.11	2.85 ± 2.29	0.017
Creatinine (mg/dL)	1.02 ± 0.56	1.14 ± 0.61	0.18
Albumin (g/L)	31.3 ± 7.7	33.0 ± 7.7	0.586
GEC (mmol/min)	1.79 ± 0.48	1.61 ± 0.41	0.081
MELD (score) (n = 18)1	11 (6)	13 (7)	0.804
Blood glucose (mmol/L)	5.8 ± 1.5	6.3 ± 1.6	0.345
Plasma insulin (pmol/L)	128.9 ± 84.0	182.9 ± 100.6	0.024
HOMA-β	269 ± 409	233 ± 108	0.700
HOMA-IR	5.04 ± 4.07	7.82 ± 5.89	0.028
BMI (kg/m2)	26.2 ± 5.8	27.4 ± 5.6	0.172
FFA (mmol/L)	0.54 ± 0.23	0.89 ± 0.44	0.013
Creatinine (mg/dL)	0.98 ± 0.52	0.83 ± 0.34	0.053
Fat mass (%)	29.4 ± 7.7	27.8 ± 8.7	0.278
Fat mass (kg)	23.4 ± 10.5	22.9 ± 10.0	0.812
Dry lean mass (kg)	14.0 ± 5.8	14.8 ± 5.0	0.115
TBW (L)	32.3 ± 9.6	43.3 ± 10.3	0.017

¹Median (interquartile range). Values were obtained 2 wk before (Basal) and 52 wk after TIPS insertion. P < 0.05 is considered statically significant. TIPS: Transjugular intrahepatic porto-systemic shunt; HVPG: Hepatic venous pressure gradient; GEC: Galactose elimination capacity; MELD: Model for end-stage liver disease; HOMA: Homeostasis model assessment; IR: Insulin resistance; BMI: Body mass index; FFA: Free fatty acids; TBW: Total body water.

Table 2 Anthropometric, pressure and laboratory values recorded in 12 normal weight (NW: BMI ≤ 25 kg/m²) and in 9 overweight (OW: BMI > 25) patients with liver cirrhosis (mean ± SD)

Variable		Basal Pre-TIPS	After 52 wk	P
HVPG (mmHg)	NW	16.4 ± 5.0	6.3 ± 2.3	< 0.001
	OW	15.0 ± 4.7	5.7 ± 2.1	< 0.001
Albumin (g/L)	NW	30.8 ± 8.4	32.6 ± 8.1	0.871
	OW	31.9 ± 7.1	33.4 ± 7.6	0.581
Bilirubin (mg/dL)	NW	1.20 ± 0.47	3.21 ± 2.82	0.061
	OW	1.71 ± 0.81	2.44 ± 1.61	0.164
GEC (mmol/min)	NW	1.62 ± 0.36	1.57 ± 0.47	0.623
	OW	1.96 ± 0.55	1.65 ± 0.36	0.088
MELD (score) (n = 9)	NW	11 (5)	13 (4)	0.727
	OW	11 (6)	12 (8)	0.289
Blood glucose (mmol/L)	NW	5.7 ± 1.5	5.7 ± 0.8	0.941
	OW	5.9 ± 1.5	6.8 ± 1.9	0.271
Insulin (pmol/L)	NW	88.9 ± 49.2	164.7 ± 106.9	0.009
	OW	171.4 ± 94.4	203.0 ± 94.9	0.466
HOMA-β	NW	152 ± 88	253 ± 118	0.042
	OW	413 ± 588	209 ± 95	0.316
HOMA-IR	NW	3.36 ± 2.18	6.18 ± 4.82	0.023
	OW	6.91 ± 4.94	9.64 ± 6.70	0.262
BMI (kg/m2)	NW	21.4 ± 2.6	24.1 ± 4.0	0.220
	OW	30.9 ± 3.7	30.8 ± 5.1	0.944
FFA (mmol/L)	NW	0.49 ± 0.22	0.86 ± 0.53	0.124
	OW	0.59 ± 0.24	0.93 ± 0.34	0.023
Creatinine (mg/dL)	NW	0.84 ± 0.43	0.76 ± 0.39	0.149
	OW	1.17 ± 0.59	0.92 ± 0.26	0.157
Fat mass (%)	NW	27.6 ± 7.2	25.3 ± 8.3	0.334
	OW	31.5 ± 7.9	30.5 ± 8.7	0.638
Fat mass (kg)	NW	16.9 ± 3.7	17.5 ± 6.7	0.782
	OW	30.5 ± 11.0	28.8 ± 9.9	0.649
Dry lean mass (kg)	NW	10.9 ± 5.9	12.7 ± 5.6	0.031
	OW	17.4 ± 3.3	17.1 ± 2.9	0.557
TBW (L)	NW	34.5 ± 7.6	40.2 ± 10.8	0.007
	OW	44.6 ± 8.9	46.6 ± 9.2	0.459

P < 0.05 is considered statistically significant.